INT123757

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.41
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
testis 1
cerebral cortex 1
synapses 1
Snap25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 1 100.00 Very High Very High Very High
Thalamus 1 100.00 Very High Very High Very High
anesthesia 5 99.98 Very High Very High Very High
isoflurane 1 97.96 Very High Very High Very High
Versed 1 94.08 High High
Hippocampus 1 90.88 High High
Pain 1 88.20 High High
Neurotransmitter 1 77.24 Quite High
Morphine 2 50.00 Quite Low
narcan 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 1 95.04 Very High Very High Very High
Pain 1 88.20 High High
Wrinkles 1 87.12 High High
Apoptosis 3 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that catalytically active BoNT/A is retrogradely transported by central neurons and motoneurons and is then transcytosed to afferent synapses, in which it cleaves SNAP-25.
Positive_regulation (cleaves) of SNAP-25 in synapses
1) Confidence 0.47 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18385327 Disease Relevance 0.18 Pain Relevance 0.17
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Positive_regulation (causes) of SNAP-25 in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
2) Confidence 0.46 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.16 Pain Relevance 0.60
The inhibiting effect of L-NNA on the abstinent syndrome, and the testis apoptosis, NOS positive cells, calmodulin (CaM) contents, superoxide dismutase (SOD) activity, and glutathione super oxidase (GSHPx) activity of the morphine-dependent rats induced by naloxone were observed and recorded by radioimmunoassay, atomic absorption spectrometry, in situ nick translation (ISNT) and NADPH-d histochemical technique.
Positive_regulation (induced) of glutathione super oxidase in testis
3) Confidence 0.02 Published 2004 Journal Zhonghua Nan Ke Xue Section Body Doc Link 15595686 Disease Relevance 0.08 Pain Relevance 0

General Comments

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