INT123758

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gpx1) aging (Gpx1) lipid metabolic process (Gpx1)
cytoplasm (Gpx1) cytosol (Gpx1) cell proliferation (Gpx1)
Anatomy Link Frequency
embryos 1
thyroid 1
testis 1
Gpx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 2 50.00 Quite Low
Kinase C 9 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
narcan 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 21 98.32 Very High Very High Very High
Diabetes Mellitus 150 97.08 Very High Very High Very High
Parkinson's Disease 3 94.20 High High
Apoptosis 35 92.80 High High
Exencephaly /

Neural Tube Defects

6 77.44 Quite High
Congenital Anomalies 24 74.40 Quite High
Gestational Diabetes 27 66.64 Quite High
Toxicity 11 50.00 Quite Low
Thyroid Neoplasm 18 22.12 Low Low
Hyperplasia 6 8.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The net effect of the Gpx-1 deficiency (further enhanced by the decreased levels of the other AOEs) would be enhanced cellular damage, as suggested by mice with a targeted Gpx-1 mutation; they display mitochondrial dysfunction (53) and apoptosis (54)¬óchanges that are in line with a teratological disturbance of normal development.
Positive_regulation (enhanced) of Gpx-1 associated with parkinson's disease and apoptosis
1) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.60 Pain Relevance 0
The Gpx-1 mRNA was markedly decreased and the VEGF-A mRNA was markedly increased in malformed compared with nonmalformed embryos from the same litter of diabetic rats.
Positive_regulation (increased) of Gpx-1 in embryos associated with diabetes mellitus
2) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.45 Pain Relevance 0
The inhibiting effect of L-NNA on the abstinent syndrome, and the testis apoptosis, NOS positive cells, calmodulin (CaM) contents, superoxide dismutase (SOD) activity, and glutathione super oxidase (GSHPx) activity of the morphine-dependent rats induced by naloxone were observed and recorded by radioimmunoassay, atomic absorption spectrometry, in situ nick translation (ISNT) and NADPH-d histochemical technique.
Positive_regulation (induced) of GSHPx in testis
3) Confidence 0.41 Published 2004 Journal Zhonghua Nan Ke Xue Section Body Doc Link 15595686 Disease Relevance 0.08 Pain Relevance 0
Other antioxidant gene transcripts were induced in the rat thyroid after NaI exposure, including Gpx1 and Gpx2 (1.4- and 2.4-fold, respectively), Sod2 (1.6 fold), Txnrd1 (1.5-fold), heme oxygenase (Hmox1, 1.9-fold), and NAD(P)H dehydrogenase quinone (Nqo1, 2.2-fold; Table 5).
Positive_regulation (induced) of Gpx1 in thyroid
4) Confidence 0.30 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.23 Pain Relevance 0
The relative abundance of mRNA/G6PDH in each sample was determined using the following equation to yield the ratio sample to G6PDH:

Immunohistochemistry of activated (cleaved) caspase-3 and Gpx-1.

Positive_regulation (activated) of Gpx-1
5) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.06 Pain Relevance 0

General Comments

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