INT123778

Context Info Confidence 0.25 First Reported 2005 Last Reported 2005 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.51 Pain Relevance 1.34

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 35 96.56 metalloproteinase 98 93.88 cytokine 3 87.88 Snapping jaw 6 82.60 Pain 3 5.00 rheumatoid arthritis 3 5.00 Spinal cord 2 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Hypoxia 9 99.72 Breast Cancer 118 98.72 Osteoarthritis 36 96.56 Temporomandibular Joint Syndrome 6 82.60 Osteoporosis 13 69.76 Osteolysis 4 51.60 Cancer 36 51.16 Apoptosis 14 46.48 Skin Cancer 2 41.56 Reprotox - General 1 2 40.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, PKA activation seems to be less required for the ET-1-induced upregulation of MMP-13 and not at all necessary for the upregulation of MMP-1 since the inhibition of PKA with KT5720 does not affect the ET-1-induced overproduction of this enzyme.

Neg (not) Positive_regulation (necessary) of Positive_regulation (upregulation) of MMP-13

1) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.26 Pain Relevance 0.14

However, our demonstration of a direct requirement of plasmin in the activation of proMMP-13 suggests that this fibrillar collagenase may play a prominent role in the degradative activity of breast cancer cells.

Positive_regulation (requirement) of Positive_regulation (activation) of proMMP-13 associated with breast cancer

2) Confidence 0.20 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.55 Pain Relevance 0.26

However, our demonstration of a direct requirement of plasmin in the activation of proMMP-13 suggests that this fibrillar collagenase may play a prominent role in the degradative activity of breast cancer cells.

Positive_regulation (role) of Positive_regulation (activation) of proMMP-13 associated with breast cancer

3) Confidence 0.20 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.52 Pain Relevance 0.27

The results showed that the combination of hypoxia and IL-1beta caused a significant increase of MMP-1, MMP-3, MMP-9 and MMP-13 mRNA (P < 0.05).

Positive_regulation (caused) of Positive_regulation (caused) of MMP-13 associated with hypoxia

4) Confidence 0.03 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 15598420 Disease Relevance 1.18 Pain Relevance 0.68

General Comments

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