INT123784

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.41
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bid) mitochondrion (Bid) cytoplasm (Bid)
Anatomy Link Frequency
neurons 2
cleavage 2
Bid (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 12 99.08 Very High Very High Very High
cytokine 2 82.48 Quite High
pregabalin 73 79.68 Quite High
Pain score 12 75.96 Quite High
anesthesia 1 59.68 Quite High
Pain 44 56.16 Quite High
diabetic neuropathy 22 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dizziness 4 99.22 Very High Very High Very High
Hypoxia 5 98.22 Very High Very High Very High
Increased Venous Pressure Under Development 1 97.74 Very High Very High Very High
Hypertension 1 97.26 Very High Very High Very High
Death 86 96.96 Very High Very High Very High
Weight Gain 6 96.76 Very High Very High Very High
Pressure And Volume Under Development 15 96.44 Very High Very High Very High
Cv General 4 Under Development 2 92.72 High High
Injury 10 91.72 High High
Apoptosis 64 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mild overexpression of FL-Bid or a Bid mutant that can not be cleaved by caspase-8 potently induces cell death in cultured rat hippocampal neurons
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bid in neurons associated with death
1) Confidence 0.40 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.34 Pain Relevance 0
This pathway did not require the generation of the caspase-8-generated cleavage product tBid.
Neg (not) Positive_regulation (require) of Gene_expression (generation) of tBid in cleavage
2) Confidence 0.40 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.23 Pain Relevance 0.09
The effects of prolonged ANG II to cause hypertension, renal vasoconstriction, renal cortical hypoxia, and reduced efficiency of O(2) usage for Na(+) transport, activation of NADPH oxidase, increased expression of p22(phox), and reduced expression of EC-SOD can be ascribed to O(2)(-). generation because they are prevented by an SOD mimetic.
Positive_regulation (increased) of Gene_expression (expression) of p22 associated with hypoxia, hypertension and increased venous pressure under development
3) Confidence 0.08 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15598867 Disease Relevance 0.37 Pain Relevance 0.06
There was no consistent pattern in TEAE incidence rates by dosing regimen, with some TEAEs, such as peripheral edema and weight gain, having greater incidence in the BID dosing groups relative to the TID dosing groups, while other TEAEs, such as dizziness and somnolence, occurred with greater frequency in the TID than the BID groups.
Positive_regulation (frequency) of Gene_expression (groups) of BID associated with pressure and volume under development, dizziness and weight gain
4) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2453685 Disease Relevance 0.48 Pain Relevance 0.51

General Comments

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