INT123787

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 16.00
Pain Relevance 6.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bid) mitochondrion (Bid) cytoplasm (Bid)
Anatomy Link Frequency
neurons 5
plasma 1
adult nervous system 1
PSCs 1
cleavage 1
Bid (Rattus norvegicus)
Bid - D59A (1)
Pain Link Frequency Relevance Heat
Duloxetine 276 100.00 Very High Very High Very High
Pain 466 99.44 Very High Very High Very High
pregabalin 190 99.00 Very High Very High Very High
Glutamate receptor 84 98.60 Very High Very High Very High
diabetic neuropathy 70 98.60 Very High Very High Very High
Chronic pancreatitis 2 98.12 Very High Very High Very High
depression 36 92.48 High High
anesthesia 6 91.52 High High
allodynia 12 91.00 High High
isoflurane 1 90.24 High High
Disease Link Frequency Relevance Heat
Death 649 100.00 Very High Very High Very High
Apoptosis 622 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 10 100.00 Very High Very High Very High
Neurodegenerative Disease 18 99.80 Very High Very High Very High
Pain 510 99.44 Very High Very High Very High
Infection 48 98.64 Very High Very High Very High
Dizziness 16 98.62 Very High Very High Very High
Diabetic Neuropathy 32 98.60 Very High Very High Very High
Pancreatitis 2 98.12 Very High Very High Very High
Hypoxia 30 98.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cells will subsequently undergo plasma membrane leakage, a process that may limit the ability to detect Bid cleavage during the late stages of apoptosis.
Gene_expression (cleavage) of Bid in plasma associated with apoptosis
1) Confidence 0.66 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.70 Pain Relevance 0.03
Interestingly and in contrast to most BH3 only proteins, Bid expression remains high in the adult nervous system [29].
Gene_expression (expression) of Bid in adult nervous system
2) Confidence 0.59 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.62 Pain Relevance 0.10
Interestingly, overexpression of Bid(D59A) also potently induced cell death in the hippocampal neuron cultures, reaching a level of 73.5 ± 3.1% after 24 h (p > 0.1, no significant difference compared to FL-Bid induced cultures).


Gene_expression (overexpression) of Bid in neuron associated with death
3) Confidence 0.59 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.82 Pain Relevance 0.04
Control experiments demonstrated that the antibody was able to detect FL-Bid and its caspase-generated NH2-terminal p7 fragment in HeLa D98 cells after an activation of death receptors with TNF-?
Gene_expression (detect) of Bid in HeLa associated with death
4) Confidence 0.58 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.78 Pain Relevance 0.07
Cultured rat hippocampal neurons were infected with adenoviral vectors expressing either FL-Bid or a Bid mutant that can not be cleaved by caspase-8 (D59A) under the control of a tetracycline responsive promoter [32].
Gene_expression (expressing) of Bid in neurons
5) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.40 Pain Relevance 0
Mild overexpression of FL-Bid or a Bid mutant that can not be cleaved by caspase-8 potently induces cell death in cultured rat hippocampal neurons
Gene_expression (overexpression) of Bid in neurons associated with death
6) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.34 Pain Relevance 0
Mild overexpression of FL-Bid or a Bid mutant that can not be cleaved by caspase-8 potently induces cell death in cultured rat hippocampal neurons
Gene_expression (overexpression) of Bid in neurons associated with death
7) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.34 Pain Relevance 0
Cultured rat hippocampal neurons were infected with adenoviral vectors expressing either FL-Bid or a Bid mutant that can not be cleaved by caspase-8 (D59A) under the control of a tetracycline responsive promoter [32].
Gene_expression (expressing) of Bid in neurons
8) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.40 Pain Relevance 0
Generation of adenoviral vectors expressing FL-Bid or FL-Bid(D59A) in an inducible system and infection protocol
Gene_expression (expressing) of Bid associated with infection
9) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.41 Pain Relevance 0.09
Tetracycline (tet)-on inducible adenovirus vectors expressing wild-type FL-Bid or the D59A mutant of FL-Bid that can not be cleaved by caspase-8 were generated as described previously [32].
Gene_expression (expressing) of Bid
10) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.42 Pain Relevance 0.08
Bid is highly expressed in the nervous system during embryonic and postnatal development.
Gene_expression (expressed) of Bid in nervous system
11) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.65 Pain Relevance 0.09
Generation of adenoviral vectors expressing FL-Bid or FL-Bid(D59A) in an inducible system and infection protocol
Gene_expression (expressing) of Bid (D59A) associated with infection
12) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.41 Pain Relevance 0.09
Tetracycline (tet)-on inducible adenovirus vectors expressing wild-type FL-Bid or the D59A mutant of FL-Bid that can not be cleaved by caspase-8 were generated as described previously [32].
Gene_expression (expressing) of Bid
13) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 0.43 Pain Relevance 0.08
This pathway did not require the generation of the caspase-8-generated cleavage product tBid.
Gene_expression (generation) of tBid in cleavage
14) Confidence 0.52 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.22 Pain Relevance 0.09
, Cytochrome C, mitochondrial membrane morphological changes, caspase 9, and expressions of Bad, Bid, Bcl-xL.
Gene_expression (expressions) of Bid
15) Confidence 0.35 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 0.92 Pain Relevance 0
The only group difference was for high density lipoprotein (HDL) between the duloxetine 60 mg bid and placebo treatment arms; however, the difference (0.027) is not clinically significant.


Gene_expression (was) of bid in arms associated with duloxetine and disorder of lipid metabolism
16) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 0.27 Pain Relevance 0.20
The investigators in all three studies concluded that duloxetine 60 mg qd and 60 mg bid were effective for treating pain associated with diabetic neuropathy.
Gene_expression (effective) of bid associated with pain, diabetic neuropathy and duloxetine
17) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 1.07 Pain Relevance 1.18
Activation of caspase 9 is prevented by a balance being maintained between prosurvival Bcl-2 and Bcl-XL and pro-death Bad, Bid, Bim, Bax, Bak and others.
Gene_expression (prosurvival) of Bid associated with death
18) Confidence 0.23 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.76 Pain Relevance 0
Six patients received CP-690 550 5 mg twice daily (BID), 6 patients received 15 mg BID, 10 patients received 30 mg BID, and 6 patients received placebo.
Gene_expression (received) of BID
19) Confidence 0.15 Published 2008 Journal Am. J. Transplant. Section Abstract Doc Link 18557720 Disease Relevance 0.43 Pain Relevance 0.17
The effects of prolonged ANG II to cause hypertension, renal vasoconstriction, renal cortical hypoxia, and reduced efficiency of O(2) usage for Na(+) transport, activation of NADPH oxidase, increased expression of p22(phox), and reduced expression of EC-SOD can be ascribed to O(2)(-). generation because they are prevented by an SOD mimetic.
Gene_expression (expression) of p22 associated with hypoxia, hypertension and increased venous pressure under development
20) Confidence 0.09 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15598867 Disease Relevance 0.37 Pain Relevance 0.06

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