INT123795

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.53
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNQ1) transmembrane transport (KCNQ1)
Anatomy Link Frequency
neuronal 1
neurons 1
KCNQ1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anticonvulsant 4 99.96 Very High Very High Very High
withdrawal 8 99.40 Very High Very High Very High
Neuropathic pain 9 97.56 Very High Very High Very High
Action potential 9 96.88 Very High Very High Very High
potassium channel 25 91.96 High High
sodium channel 7 91.04 High High
Neurotransmitter 9 88.40 High High
action potential duration 1 86.48 High High
diclofenac 5 82.80 Quite High
cINOD 1 77.80 Quite High
Disease Link Frequency Relevance Heat
Syndrome 139 97.76 Very High Very High Very High
Neuropathic Pain 9 97.56 Very High Very High Very High
Nociception 2 96.44 Very High Very High Very High
Toxicity 1 89.20 High High
Cv General 2 Under Development 1 87.60 High High
Epilepsy 9 84.08 Quite High
Symphalangism 2 82.72 Quite High
Cognitive Disorder 7 81.32 Quite High
Death 6 81.32 Quite High
Malignant Neoplastic Disease 4 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mutation furthermore increased the sensitivity of KCNQ1/KCNE1 channels for bupivacaine 22-fold (KCNQ1wt/KCNE1: IC50 = 2,431 +/- 582 microM, n = 20; KCNQ1A344V/KCNE1: IC50 = 110 +/- 9 microM, n = 24).
Positive_regulation (increased) of KCNQ1
1) Confidence 0.49 Published 2006 Journal Anesthesiology Section Body Doc Link 16931984 Disease Relevance 0.08 Pain Relevance 0
RESULTS: The mutation A344V induced voltage-dependent inactivation in homomeric KCNQ1 channels and shifted the voltage dependence of KCNQ1/KCNE1 channel activation by +30 mV.
Positive_regulation (activation) of KCNQ1
2) Confidence 0.47 Published 2006 Journal Anesthesiology Section Body Doc Link 16931984 Disease Relevance 0.08 Pain Relevance 0
This might become LQT10.


Spec (might) Positive_regulation (become) of LQT10
3) Confidence 0.39 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.11 Pain Relevance 0.15
It has been shown that retigabine, a novel anticonvulsant, activates Kv7 (KCNQ/M) channels in the axonal/nodal membrane of peripheral myelinated axons.
Positive_regulation (activates) of Kv7 associated with anticonvulsant
4) Confidence 0.37 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18474382 Disease Relevance 0.19 Pain Relevance 0.19
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Positive_regulation (activation) of Kv7
5) Confidence 0.25 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.25 Pain Relevance 0.20
Further, the compound enhanced the maximal current amplitude at all potentials for Kv7.4 and Kv7.5 whereas the combined activation/block of Kv7.2 and Kv7.2/3 was strongly voltage-dependent.
Positive_regulation (enhanced) of Kv7
6) Confidence 0.25 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.24 Pain Relevance 0.20
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Positive_regulation (activation) of Kv7
7) Confidence 0.25 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.25 Pain Relevance 0.20
Further, the compound enhanced the maximal current amplitude at all potentials for Kv7.4 and Kv7.5 whereas the combined activation/block of Kv7.2 and Kv7.2/3 was strongly voltage-dependent.
Positive_regulation (enhanced) of Kv7
8) Confidence 0.25 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.24 Pain Relevance 0.20
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Positive_regulation (activation) of Kv7
9) Confidence 0.25 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.25 Pain Relevance 0.20
In contrast, (S)-1 produced a hyperpolarizing shift of the activation curve for Kv7.2, Kv7.2/Kv7.3, Kv7.4 and Kv7.5.
Positive_regulation (activation) of Kv7
10) Confidence 0.25 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.25 Pain Relevance 0.20
In contrast, they did not enhance KCNQ1 K(+) currents.
Neg (not) Positive_regulation (enhance) of KCNQ1 K
11) Confidence 0.02 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15598972 Disease Relevance 0.21 Pain Relevance 0.57
By contrast, activation of KCNQ K+ channels seemed not to be involved in retigabine-induced OHSCs neuroprotection during SW, since linopirdine (20 microM) and XE-991 (10 microM), two KCNQ blockers, failed to reverse retigabine-induced neuronal rescue.
Positive_regulation (activation) of KCNQ K in neuronal associated with withdrawal
12) Confidence 0.01 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16697426 Disease Relevance 0.38 Pain Relevance 0.35
Hence, activated KCNQ channels keep neurons polarized, and closure of these ion channels causes depolarization and increased action potential discharge [61, 62].
Positive_regulation (activated) of KCNQ in neurons associated with action potential
13) Confidence 0.01 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.18

General Comments

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