INT12380

Context Info Confidence 0.80 First Reported 1981 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 10 Total Number 10 Disease Relevance 0.07 Pain Relevance 4.70

methyltransferase activity (Pnmt) cytoplasm (Pnmt)

Anatomy Link Frequency peptidergic neurons 2 adrenal medulla 1 adrenal gland 1 Pnmt (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 57 100.00 Catecholamine 11 100.00 Dopamine 6 100.00 Opioid 6 100.00 Neuropeptide 6 99.60 substance P 8 99.00 medulla 19 98.32 Locus ceruleus 12 98.28 potassium channel 2 89.24 Endogenous opioid 2 77.76

Disease Link Frequency Relevance Heat Fetal Weight 1 68.64 Increased Venous Pressure Under Development 2 41.60 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both PNMT mRNA and ProEnk A mRNA co-localized in cells at the outer margin of foetal adrenal of late gestations (110-140 days), a similar pattern to that seen in the adult adrenal medulla.

Localization (localized) of PNMT mRNA in adrenal medulla associated with medulla

1) Confidence 0.80 Published 1989 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 2816486 Disease Relevance 0 Pain Relevance 0.42

The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.

Localization (localization) of PNMT in peptidergic neurons associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p

2) Confidence 0.78 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.42

Thus, the present study combined the immunocytochemical localization of the opioid peptide leucine5-enkephalin (ENK) and the epinephrine synthesizing enzyme, phenylethanolamine-N-methyltransferase (PNMT) in the same section of tissue within the LC at the electron microscopic level.

Localization (localization) of PNMT associated with locus ceruleus, enkephalin and opioid

3) Confidence 0.78 Published 1996 Journal Brain Res. Section Abstract Doc Link 8925305 Disease Relevance 0 Pain Relevance 1.02

Thus, the present study combined the immunocytochemical localization of the opioid peptide leucine5-enkephalin (ENK) and the epinephrine synthesizing enzyme, phenylethanolamine-N-methyltransferase (PNMT) in the same section of tissue within the LC at the electron microscopic level.

Localization (localization) of phenylethanolamine-N-methyltransferase associated with locus ceruleus, enkephalin and opioid

4) Confidence 0.77 Published 1996 Journal Brain Res. Section Abstract Doc Link 8925305 Disease Relevance 0 Pain Relevance 1.02

The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.

Localization (localization) of phenylethanolamine-N-methyltransferase in peptidergic neurons associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p

5) Confidence 0.76 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.42

Co-localization of RNAs coding for phenylethanolamine N-methyltransferase and proenkephalin A in bovine and ovine adrenals.

Localization (Co-localization) of phenylethanolamine N-methyltransferase associated with enkephalin

6) Confidence 0.66 Published 1989 Journal J. Auton. Nerv. Syst. Section Title Doc Link 2754179 Disease Relevance 0 Pain Relevance 0.16

We have investigated the effect of fetal hypophysectomy on the localization of dopamine B-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT) and enkephalin-containing peptides in the fetal sheep adrenal, using immunocytochemical techniques.

Localization (localization) of phenylethanolamine N-methyltransferase associated with dopamine and enkephalin

7) Confidence 0.29 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2754370 Disease Relevance 0 Pain Relevance 0.38

A preferential co-localization of NESP55 with phenylethanolamine-N-methyltransferase in the adrenergic cell population was found by immunolabelling of consecutive sections.

Localization (co-localization) of phenylethanolamine-N-methyltransferase

8) Confidence 0.26 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10218899 Disease Relevance 0 Pain Relevance 0.12

We have investigated the effect of adrenocorticotrophic hormone (ACTH) replacement after fetal hypophysectomy on the pattern of localization of enkephalin-containing peptides (enkephalins) and phenylethanolamine N-methyltransferase (PNMT) in the fetal sheep adrenal.

Localization (localization) of phenylethanolamine N-methyltransferase associated with enkephalin

9) Confidence 0.17 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1645853 Disease Relevance 0 Pain Relevance 0.32

The aims of this study were to determine whether placental restriction (PR) alters the pattern of localization of the catecholamine-synthesizing enzymes, dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase, and enkephalin (ENK)-containing peptides in the adrenal gland of the midgestation sheep fetus.

Localization (localization) of phenylethanolamine N-methyltransferase in adrenal gland associated with dopamine, catecholamine and enkephalin

10) Confidence 0.15 Published 1998 Journal Pediatr. Res. Section Abstract Doc Link 9803446 Disease Relevance 0.07 Pain Relevance 0.42

General Comments

This test has worked.