INT123813

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 74
Total Number 82
Disease Relevance 65.36
Pain Relevance 8.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
poly 9
lung 7
cleavage 6
bladder 6
A549 3
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 1 100.00 Very High Very High Very High
Paracetamol 70 99.84 Very High Very High Very High
Inflammation 627 99.20 Very High Very High Very High
Hyperalgesia 7 98.86 Very High Very High Very High
Spinal cord 164 98.80 Very High Very High Very High
hypoalgesia 3 97.72 Very High Very High Very High
ischemia 77 96.96 Very High Very High Very High
Morphine 9 96.72 Very High Very High Very High
imagery 161 96.32 Very High Very High Very High
Brush evoked pain 3 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 474 99.98 Very High Very High Very High
Apoptosis 1635 99.96 Very High Very High Very High
Stress 140 99.90 Very High Very High Very High
Pancreatic Cancer 305 99.84 Very High Very High Very High
Cancer 2136 99.78 Very High Very High Very High
Hepatotoxicity 8 99.68 Very High Very High Very High
Adult Respiratory Distress Syndrome 332 99.62 Very High Very High Very High
Lung Injury 1047 99.56 Very High Very High Very High
Overdose 22 99.56 Very High Very High Very High
Aging 15 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, PARP-1 activation is not a relevant event for AAP-induced oncotic necrosis.
Positive_regulation (activation) of PARP-1 associated with necrosis and paracetamol
1) Confidence 0.70 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.65 Pain Relevance 0.59
Few nuclei of hepatocytes stained positive for poly-ADP-ribosylated nuclear proteins (PAR) as indicator for PARP-1 activation at 4.5 h.
Positive_regulation (activation) of PARP-1 in poly
2) Confidence 0.70 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.59 Pain Relevance 0.54
In summary, PARP-1 activation is a consequence of DNA fragmentation after AAP overdose.
Positive_regulation (activation) of PARP-1 associated with paracetamol and overdose
3) Confidence 0.70 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.65 Pain Relevance 0.64
Based on controversial findings with chemical PARP inhibitors, the role of PARP-1 activation in AAP hepatotoxicity remains unclear.
Positive_regulation (activation) of PARP-1 associated with paracetamol and hepatotoxicity
4) Confidence 0.70 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.45 Pain Relevance 0.43
The orally active PARP inhibitor 10-(4-methylpiperazin-1-ylmethyl)-2H-7-oxa-1,2-diaza-benzo[de]anthracen-3-one (GPI-15427; formulated as a mesilate salt, 30 mg kg(-1) day(-1) in the drinking water for 10 weeks after the first 2 weeks without treatment) at least partially prevented PARP activation in peripheral nerve and DRG neurons, as well as thermal hypoalgesia, mechanical hyperalgesia, tactile allodynia, exaggerated response to formalin, and, most importantly, intraepidermal nerve fiber degeneration in streptozotocin-diabetic rats.
Positive_regulation (activation) of PARP in neurons associated with brush evoked pain, hyperalgesia, diabetes mellitus and hypoalgesia
5) Confidence 0.69 Published 2008 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17976390 Disease Relevance 0.91 Pain Relevance 0.45
In conclusion, PARP activation is an important contributor to intraepidermal nerve fiber degeneration and functional changes associated with advanced Type 1 diabetic neuropathy.
Positive_regulation (activation) of PARP in nerve associated with diabetic neuropathy
6) Confidence 0.69 Published 2008 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17976390 Disease Relevance 0.98 Pain Relevance 0.44
These results suggest that activation of NMDA receptors and PARP play an important role in the increased lethality induced by methamphetamine and morphine.
Positive_regulation (activation) of PARP associated with nmda receptor and morphine
7) Confidence 0.69 Published 2005 Journal J. Pharmacol. Sci. Section Abstract Doc Link 16210775 Disease Relevance 0.09 Pain Relevance 0.78
Poly(ADP-ribose) polymerase (PARP-1) is a nuclear enzyme which is activated in response to genotoxic insults by binding damaged DNA and attaching polymers of ADP-ribose to nuclear proteins at the expense of its substrate NAD+.
Positive_regulation (activated) of PARP-1 in Poly
8) Confidence 0.69 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.16 Pain Relevance 0
Furthermore, PARP-1 is activated by agents infringing single stranded DNA damage such as alkylating agents, ionizing radiation, and oxidative damage.
Positive_regulation (activated) of PARP-1
9) Confidence 0.69 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.10 Pain Relevance 0
The primary purpose of our study was to investigate the roles of stretch and shearing forces by injurious MV in PARP activation using the VILI model of healthy animals.
Spec (investigate) Positive_regulation (activation) of PARP associated with lung injury
10) Confidence 0.67 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.81 Pain Relevance 0
Through this model, we could examine and conclude that the injurious MV itself could induce the PARP activation and the PARP inhibitor could protect the injury by PARP activation, regardless of primary insult of ALI.
Positive_regulation (activation) of PARP associated with injury and adult respiratory distress syndrome
11) Confidence 0.67 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.02 Pain Relevance 0
Thereafter, PARP activity increased at 1 and 0.5 hours.
Positive_regulation (increased) of PARP
12) Confidence 0.67 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.53 Pain Relevance 0.04
However, until recently, the role of PARP activation has not been elucidated in severe inflammatory lung injury of VILI.
Positive_regulation (activation) of PARP in lung associated with lung injury and inflammation
13) Confidence 0.67 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.94 Pain Relevance 0.19
Effect of GW0742 -treatment on nitrosative stress and PARP activation
Positive_regulation (activation) of PARP associated with stress
14) Confidence 0.59 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.39 Pain Relevance 0.03
DNA strandbreaks can induce excessive activation of poly(ADP-ribose) polymerases (PARP), which may lead to oncotic necrosis.
Positive_regulation (activation) of PARP in poly associated with necrosis
15) Confidence 0.50 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.43 Pain Relevance 0.43
To investigate PARP-1 activation and evaluate a pathophysiological role of PARP-1, we used both PARP inhibitors (3-aminobenzamide; 5-aminoisoquinolinone) and PARP gene knockout mice (PARP-/-).
Positive_regulation (role) of PARP-1 associated with targeted disruption
16) Confidence 0.50 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.45 Pain Relevance 0.48
To investigate PARP-1 activation and evaluate a pathophysiological role of PARP-1, we used both PARP inhibitors (3-aminobenzamide; 5-aminoisoquinolinone) and PARP gene knockout mice (PARP-/-).
Spec (investigate) Positive_regulation (activation) of PARP-1 associated with targeted disruption
17) Confidence 0.50 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.45 Pain Relevance 0.43
Evidence that poly(ADP-ribose) polymerase (PARP) activation plays an important role in diabetic complications is emerging.
Positive_regulation (activation) of PARP in poly associated with diabetes complications
18) Confidence 0.50 Published 2008 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17976390 Disease Relevance 0.51 Pain Relevance 0.33
This model is clinically relevant in studying the mechanism of ventilator-associated lung injury, which refers to the additional injury imposed on a previously injured lung by MV in either the clinical setting or experimental studies [15,16], but intratracheal administration of LPS has been reported to induce PARP overactivation in the lung tissue [12].
Positive_regulation (overactivation) of PARP in lung associated with lung injury and injury
19) Confidence 0.48 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.22 Pain Relevance 0.06
The purpose of this study was to examine the role of injurious MV strategy in PARP activation and the effects of a PARP inhibitor, in the mouse VILI model of normal lung, under the hypothesis that PARP overactivation may participate in inflammatory and transcriptional mechanisms of VILI.


Positive_regulation (overactivation) of PARP in lung associated with lung injury and inflammation
20) Confidence 0.48 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.14 Pain Relevance 0.15

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