INT123814

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.32
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
poly 2
bladder 2
lung 2
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 10 98.36 Very High Very High Very High
Demyelination 12 83.12 Quite High
Multiple sclerosis 62 72.64 Quite High
Inflammation 67 63.80 Quite High
ischemia 11 58.28 Quite High
rheumatoid arthritis 4 23.76 Low Low
Arthritis 1 15.20 Low Low
cytokine 24 11.60 Low Low
corticosteroid 1 8.96 Low Low
Endocannabinoid 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 122 99.84 Very High Very High Very High
Apoptosis 173 98.92 Very High Very High Very High
Necrosis 20 98.84 Very High Very High Very High
Overdose 2 98.76 Very High Very High Very High
Cancer 148 98.32 Very High Very High Very High
Injury 58 98.32 Very High Very High Very High
Overactive Bladder 12 97.12 Very High Very High Very High
Adult Respiratory Distress Syndrome 68 95.96 Very High Very High Very High
Lung Injury 204 95.84 Very High Very High Very High
Skin Cancer 53 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNA strandbreaks can induce excessive activation of poly(ADP-ribose) polymerases (PARP), which may lead to oncotic necrosis.
Positive_regulation (induce) of Positive_regulation (activation) of PARP in poly associated with necrosis
1) Confidence 0.50 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.43 Pain Relevance 0.43
This model is clinically relevant in studying the mechanism of ventilator-associated lung injury, which refers to the additional injury imposed on a previously injured lung by MV in either the clinical setting or experimental studies [15,16], but intratracheal administration of LPS has been reported to induce PARP overactivation in the lung tissue [12].
Positive_regulation (induce) of Positive_regulation (overactivation) of PARP in lung associated with lung injury and injury
2) Confidence 0.48 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.23 Pain Relevance 0.06
Through this model, we could examine and conclude that the injurious MV itself could induce the PARP activation and the PARP inhibitor could protect the injury by PARP activation, regardless of primary insult of ALI.
Positive_regulation (induce) of Positive_regulation (activation) of PARP associated with injury and adult respiratory distress syndrome
3) Confidence 0.48 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.95 Pain Relevance 0
Usually, PARP inactivation is dependent on caspase 3, which has a central role in the apoptosis process collecting signals coming from both intrinsic and extrinsic pathways.
Positive_regulation (dependent) of Positive_regulation (inactivation) of PARP associated with apoptosis
4) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.25 Pain Relevance 0
As shown in Fig. 2C, the accumulation of cleavaged PARP and caspase-3 was markedly increased during incubation with TNF?
Positive_regulation (accumulation) of Positive_regulation (cleavaged) of PARP
5) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.51 Pain Relevance 0
-induced activation of caspase-3 and PARP in pancreatic cancer cells
Positive_regulation (induced) of Positive_regulation (activation) of PARP associated with pancreatic cancer
6) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.60 Pain Relevance 0
Western blot analysis showed a significant increase in activation of PARP in earlier time points after bladder overdistension and subsequent emptying.
Positive_regulation (increase) of Positive_regulation (activation) of PARP in bladder
7) Confidence 0.17 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 1.09 Pain Relevance 0
Both

of which can lead to increased PARP-1 activity.

Positive_regulation (lead) of Positive_regulation (increased) of PARP-1
8) Confidence 0.12 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.45 Pain Relevance 0.08
Furthermore, ONOO- can induce excessive activation of the nuclear repair enzyme PARP [13,14], which may cause ATP depletion and cell damage [14,15].
Positive_regulation (induce) of Positive_regulation (activation) of PARP
9) Confidence 0.08 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.80 Pain Relevance 0

General Comments

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