INT123815

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 27.82
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
cleavage 7
poly 5
lung 3
embryos 1
liver 1
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
carrageenan induced 2 99.90 Very High Very High Very High
mu opioid receptor 13 99.80 Very High Very High Very High
Paracetamol 10 99.20 Very High Very High Very High
qutenza 4 98.70 Very High Very High Very High
imagery 175 95.72 Very High Very High Very High
dexamethasone 43 94.24 High High
aspirin 13 93.00 High High
Kinase C 4 92.56 High High
Inflammatory response 24 86.68 High High
iatrogenic 2 83.88 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1070 100.00 Very High Very High Very High
Injury 118 99.96 Very High Very High Very High
Cancer 1811 99.84 Very High Very High Very High
Lymphatic System Cancer 68 99.28 Very High Very High Very High
Diabetes Mellitus 327 98.86 Very High Very High Very High
Gestational Diabetes 18 98.80 Very High Very High Very High
Stress 54 98.56 Very High Very High Very High
Overactive Bladder 12 98.32 Very High Very High Very High
Necrosis 54 97.88 Very High Very High Very High
Lung Injury 219 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.
Gene_expression (role) of PARP in liver associated with necrosis and paracetamol
1) Confidence 0.67 Published 2005 Journal Toxicol. Sci. Section Title Doc Link 15601672 Disease Relevance 0.49 Pain Relevance 0.55
From the results presented here, there is a clear duality in the effect of PARP inhibition on ATM: while the lack of response to IR in ANI treated cells indicates that poly (ADP-rybosylation) of ATM is probably needed for optimal ATM activation, long term exposure to PARP inhibitor results in the generation of DSBs and secondarily in the activation of ATM kinase.
Neg (inhibition) Gene_expression (inhibition) of PARP in poly
2) Confidence 0.67 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.31 Pain Relevance 0
PARP-1 is needed for optimal activation of ATM
Gene_expression (needed) of PARP-1
3) Confidence 0.67 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.06 Pain Relevance 0
In cotransfection studies, PARP-1 repressed the MOR promoter only when the poly(C) sequence was intact.
Gene_expression (repressed) of PARP-1 in poly associated with mu opioid receptor
4) Confidence 0.66 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.59
However, under conditions of severe DNA injury, overactivation of PARP severely depletes the intracellular stores of NAD+, slowing the rate of glycolysis, mitochondrial respiration, and high-energy phosphate generation, ultimately leading to cell death via the necrotic pathway [7].
Gene_expression (overactivation) of PARP associated with injury and death
5) Confidence 0.65 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.22 Pain Relevance 0.14
In this study we demonstrate the physical interaction between PARP-1 and ATM in response to ionizing radiation, the modification of ATM by poly(ADP-ribose) and the functional consequences of this interaction in PARP-1 deficient cells, where the activation of ATM kinase is compromised in response to IR.
Gene_expression (deficient) of PARP-1 in poly
6) Confidence 0.60 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.18 Pain Relevance 0
The biological consequence of this interaction is a diminished activation of ATM-kinase in the absence of PARP-1.
Neg (absence) Gene_expression (absence) of PARP-1
7) Confidence 0.60 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.07 Pain Relevance 0
To address this question we have measured ATM kinase activity in wild type and PARP-1 deficient cells and in the presence and absence of the PARP inhibitor 4-amino,1–8,naphtalimide (ANI).
Gene_expression (deficient) of PARP-1
8) Confidence 0.60 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.09 Pain Relevance 0
Expression of PARP and protective effects of PJ34 in ventilator-induced lung injury
Gene_expression (Expression) of PARP in lung associated with lung injury
9) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.82 Pain Relevance 0
Thus, a markedly immunohistochemical staining of PARP was detected in sections of pancreas, lung and gut from zymosan-treated mice, while, here, we have observed a decrease of PARP activity in samples of mice treated with GW0742.
Gene_expression (detected) of PARP in gut
10) Confidence 0.51 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.63 Pain Relevance 0.08
As expected wild-type TFII-I was able to co-immunoprecipitate itself and PARP1, however, in the same conditions ?
Gene_expression (itself) of PARP1
11) Confidence 0.45 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2865459 Disease Relevance 0 Pain Relevance 0
As expected wild-type TFII-I was able to co-immunoprecipitate itself and PARP1, however, in the same conditions ?
Gene_expression (immunoprecipitate) of PARP1
12) Confidence 0.45 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2865459 Disease Relevance 0 Pain Relevance 0
Immunohistochemical analysis of EL4 tumor caspase-3 activation and PARP-1 cleavage and immunofluorescence analysis of in vivo tumor binding of DAB4
Gene_expression (cleavage) of PARP-1 in cleavage associated with cancer
13) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.45 Pain Relevance 0.03
Chemotherapy induced dose-dependent caspase-3 activation and PARP-1 cleavage in tumors of EL4 lymphoma-bearing mice (Figure 3).
Gene_expression (cleavage) of PARP-1 in EL4 associated with lymphatic system cancer and cancer
14) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.49 Pain Relevance 0.04
Immunohistochemical measurements of tumor caspase-3 activation and PARP-1 cleavage, which are indicators of early and late apoptosis, respectively, were correlated with tumor accumulation of DAB4.
Gene_expression (cleavage) of PARP-1 in cleavage associated with cancer and apoptosis
15) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2645692 Disease Relevance 2.18 Pain Relevance 0.05
Activated caspase-3 and cleaved PARP-1 were detected using specific rabbit IgG followed by Alexa546-conjugated goat anti-rabbit IgG (2.5 µg/mL, Molecular Probes-Invitrogen, CA).
Gene_expression (detected) of PARP-1
16) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.65 Pain Relevance 0.03
Sections were stained with hematoxylin and eosin (H&E) or rabbit IgG raised against either activated caspase-3 (1 µg/mL, Chemicon-Millipore, MA) or cleaved PARP-1 (1?
Gene_expression (cleaved) of PARP-1
17) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.46 Pain Relevance 0.10
Immunohistochemical analysis indicated that tumor activation of caspase-3 became most evident 24 hours after a full dose of chemotherapy (Figure 3A) whereas PARP-1 cleavage was best identified 96 hours post-chemotherapy (Figure 3B).
Gene_expression (cleavage) of PARP-1 in cleavage associated with cancer
18) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.58 Pain Relevance 0.05
Apoptosis was detected in tumors by immunohistochemical analysis of caspase-3 activation and cleavage of poly ADP-ribose-1 (PARP-1).
Gene_expression (cleavage) of PARP-1 in poly associated with cancer and apoptosis
19) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.63 Pain Relevance 0
Both caspase-3 activation and PARP-1 cleavage as early and late markers of apoptosis, respectively, increased directly as a function of chemotherapy dose.
Gene_expression (cleavage) of PARP-1 in cleavage associated with apoptosis
20) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.83 Pain Relevance 0

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