INT123828

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.79
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCL3) extracellular space (CCL3) extracellular region (CCL3)
intracellular (CCL3) cytoskeleton organization (CCL3) kinase activity (CCL3)
Anatomy Link Frequency
monocyte 1
T cells 1
CCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 50 99.84 Very High Very High Very High
Inflammation 34 99.68 Very High Very High Very High
chemokine 69 99.48 Very High Very High Very High
Nucleus accumbens 1 91.28 High High
Limbic system 1 89.76 High High
Hippocampus 1 88.56 High High
Thalamus 1 87.52 High High
Inflammatory mediators 1 59.32 Quite High
Pain 1 47.60 Quite Low
Opioid 1 41.20 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 10 99.84 Very High Very High Very High
INFLAMMATION 33 99.68 Very High Very High Very High
Juvenile Chronic Polyarthritis 40 97.12 Very High Very High Very High
Osteolysis 2 50.00 Quite Low
Prosthesis Failure 1 48.60 Quite Low
Pain 1 47.60 Quite Low
Frailty 1 45.72 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 9 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of the majority of genes (>95%) did not vary over time or with exposure to different biomaterials, but a few important genes, such as TNF-alpha, IL-1beta, IL-6, and MIP1alpha, proved to be highly regulated in response to biomaterial exposure.
Regulation (regulated) of MIP1alpha
1) Confidence 0.60 Published 2005 Journal Biomaterials Section Abstract Doc Link 15603788 Disease Relevance 0.06 Pain Relevance 0.03
Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis.

Regulation (targets) of CCL3 in T cells associated with chemokine, inflammation, juvenile chronic polyarthritis and arthritis
2) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1526593 Disease Relevance 0.63 Pain Relevance 0.55
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Regulation (regulated) of CCL3 in monocyte associated with chemokine and inflammation
3) Confidence 0.12 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.68

General Comments

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