INT12385

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Context Info
Confidence 0.81
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.05
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NGFR) endosome (NGFR) nucleoplasm (NGFR)
cytoplasm (NGFR) signal transducer activity (NGFR) cytosol (NGFR)
Anatomy Link Frequency
nerve 2
hinge 1
sympathetic 1
nucleus 1
NGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 13 100.00 Very High Very High Very High
bDMF 12 99.78 Very High Very High Very High
Peripheral sensitization 4 97.92 Very High Very High Very High
substance P 9 96.52 Very High Very High Very High
nociceptor 5 91.44 High High
trigeminal ganglion 1 87.28 High High
Central nervous system 10 85.80 High High
Spinal cord 18 84.56 Quite High
Hyperalgesia 10 82.32 Quite High
Neuropathic pain 14 77.80 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 99.96 Very High Very High Very High
Injury 15 98.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 147 95.44 Very High Very High Very High
Apoptosis 8 88.00 High High
Ganglion Cysts 4 86.84 High High
Hyperalgesia 12 82.32 Quite High
Neuropathic Pain 18 77.80 Quite High
Osteoporosis 2 77.56 Quite High
Hepatitis 1 77.52 Quite High
Reprotox - General 1 8 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of nerve growth factor receptor immunoreactivity in the trigeminal nucleus of kittens.
Localization (Localization) of nerve growth factor receptor in nucleus associated with nerve growth factor
1) Confidence 0.81 Published 1991 Journal Exp. Neurol. Section Title Doc Link 1646114 Disease Relevance 0.14 Pain Relevance 0.17
A final list was obtained comprising 90 genes that includes several neurotrophins (NT3 and BDNF) or their receptors (NGFR, NTRK2, and NTRK3), together with other trophic factors like BMPs, TGF?
Localization (receptors) of NGFR associated with bdmf
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.07 Pain Relevance 0.05
These osteoblasts were shown to produce nerve growth factor and brain-derived neurotrophic factor but not neurotrophin-3, as measured by ELISA. hFOB osteoblasts, cultured at 34 degrees C, secreted significantly (P < 0.01) more brain-derived neurotrophic factor and nerve growth factor into the medium than hFOB cells cultured at 39 degrees C.
Localization (secreted) of nerve growth factor in nerve associated with nerve growth factor
3) Confidence 0.43 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861369 Disease Relevance 0.76 Pain Relevance 0.10
For this C46 transgene, the signal peptide of the low-affinity nerve growth factor receptor (LNGFR) directs translocation into the endoplasmic reticulum, and the human immunoglobulin G2 (IgG2) hinge fused to the human CD34 membrane-spanning domain serves as a scaffold to anchor the peptide to the cell surface [23].
Localization (translocation) of LNGFR in hinge associated with nerve growth factor
4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.24 Pain Relevance 0.05
Histamine-induced vasodilatation, nerve growth factor release, and reflex sympathetic efferent release of norepinephrine are other processes related with peripheral sensitization.
Localization (release) of nerve growth factor in nerve associated with nerve growth factor, peripheral sensitization and increased venous pressure under development
5) Confidence 0.04 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2844689 Disease Relevance 0.92 Pain Relevance 1.54
Histamine-induced vasodilatation, nerve growth factor release, and reflex sympathetic efferent release of norepinephrine are other processes related with peripheral sensitization.
Localization (release) of nerve growth factor in sympathetic associated with nerve growth factor, peripheral sensitization and increased venous pressure under development
6) Confidence 0.04 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2844689 Disease Relevance 0.92 Pain Relevance 1.56

General Comments

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