INT123852

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.69
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
platelet 4
pancreas 2
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 1 98.16 Very High Very High Very High
fibrosis 9 96.40 Very High Very High Very High
Chronic pancreatitis 7 91.04 High High
Inflammation 6 84.32 Quite High
cytokine 2 80.32 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Fibrosis 9 96.40 Very High Very High Very High
INFLAMMATION 6 84.32 Quite High
Body Weight 1 82.72 Quite High
Pancreatitis 7 80.64 Quite High
Frailty 1 61.36 Quite High
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ellagic acid inhibited the production of reactive oxygen species in pancreatic stellate cells in response to transforming growth factor-beta1 or platelet-derived growth factor.
Negative_regulation (inhibited) of Positive_regulation (response) of transforming growth factor-beta1 in platelet
1) Confidence 0.28 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18651219 Disease Relevance 0.73 Pain Relevance 0.45
CONCLUSION: We conclude that FTY720 prevents pancreatic inflammation and fibrosis by suppressing infiltration of CD4- and CD8-positive T cells and by downregulating induction of interferon and transforming growth factor-beta1 mRNA in the pancreas.


Negative_regulation (downregulating) of Positive_regulation (induction) of transforming growth factor-beta1 mRNA in pancreas
2) Confidence 0.15 Published 2005 Journal Pancreas Section Body Doc Link 15782091 Disease Relevance 0 Pain Relevance 0
Combination therapy suppressed up-regulation of tumor necrosis factor-alpha, platelet-derived growth factor-receptor beta, and transforming growth factor-beta1 mRNA in the pancreas.
Negative_regulation (suppressed) of Positive_regulation (up-regulation) of transforming growth factor-beta1 mRNA in platelet associated with necrosis and cancer
3) Confidence 0.07 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15608084 Disease Relevance 0.96 Pain Relevance 0.48

General Comments

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