INT12386

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.15
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NGFR) endosome (NGFR) nucleoplasm (NGFR)
cytoplasm (NGFR) signal transducer activity (NGFR) cytosol (NGFR)
Anatomy Link Frequency
sympathetic 1
synovium 1
nociceptors 1
NGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 24 100.00 Very High Very High Very High
backache 1 99.24 Very High Very High Very High
primary afferent fibers 1 99.16 Very High Very High Very High
substance P 1 97.76 Very High Very High Very High
Calcitonin gene-related peptide 1 97.12 Very High Very High Very High
nociceptor 1 94.44 High High
anesthesia 1 92.12 High High
epidural 1 91.68 High High
rheumatoid arthritis 32 87.48 High High
Dorsal horn 2 87.24 High High
Disease Link Frequency Relevance Heat
Low Back Pain 1 99.24 Very High Very High Very High
Injury 35 98.36 Very High Very High Very High
Apoptosis 6 97.24 Very High Very High Very High
Pancreatic Cancer 8 95.64 Very High Very High Very High
Cancer 10 93.12 High High
Nociception 1 91.48 High High
Rheumatoid Arthritis 34 87.48 High High
Pain 6 86.80 High High
Congenital Anomalies 1 82.80 Quite High
Distal Myopathy 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it appears that NGFr-IR is associated with the endings of primary afferent fibers in the brain stem, and that these fibers may represent a certain subclass of primary afferent nociceptors.
NGFr-IR Binding (associated) of in nociceptors associated with nociceptor and primary afferent fibers
1) Confidence 0.48 Published 1991 Journal Exp. Neurol. Section Abstract Doc Link 1646114 Disease Relevance 0.15 Pain Relevance 0.42
CD271 has been associated with bone marrow-derived mesenchymal progenitor cells but does not appear to be present on expanded mesenchymal progenitor cells from the synovium [14,16,17,25].
CD271 Binding (associated) of in synovium
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.15 Pain Relevance 0.07
In a set of eight patients, staining for CD34 was combined with CD271.
CD271 Binding (combined) of
3) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.07 Pain Relevance 0.04
Although the role of the p75NTR is highly debated, it predominantly binds the precursor pro-forms of neurotrophins and has been implicated in apoptosis [28].
p75NTR Binding (binds) of associated with apoptosis
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.46 Pain Relevance 0
TrkA and p75NGFR negatively correlated and were both associated with abdominal or back pain and perineural invasion.
p75NGFR Binding (associated) of associated with backache
5) Confidence 0.15 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.10 Pain Relevance 0.51
Although the etiology of autonomic nerve disturbances in these cases remains to be elucidated, a positive immunoreactivity of nerve growth factor receptor (NGFR) implies the possibility of some unknown sympathetic neurovascular disorder involving muscle degeneration.
NGFR Binding (immunoreactivity) of in sympathetic associated with nerve growth factor
6) Confidence 0.10 Published 1994 Journal Brain Dev. Section Abstract Doc Link 8059932 Disease Relevance 0.22 Pain Relevance 0.19

General Comments

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