INT12388

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Context Info
Confidence 0.59
First Reported 1991
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 9.47
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr1) plasma membrane (Crhr1) response to stress (Crhr1)
signal transducer activity (Crhr1)
Anatomy Link Frequency
hypothalamus 1
Chromaffin cell 1
Crhr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 119 100.00 Very High Very High Very High
withdrawal 12 99.74 Very High Very High Very High
Morphine 3 99.52 Very High Very High Very High
Enkephalin 1 99.16 Very High Very High Very High
alcohol 11 98.88 Very High Very High Very High
opiate 5 98.08 Very High Very High Very High
Eae 10 97.24 Very High Very High Very High
Nucleus accumbens 2 96.64 Very High Very High Very High
amygdala 52 95.72 Very High Very High Very High
depression 33 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aggression 880 99.96 Very High Very High Very High
Stress 70 99.52 Very High Very High Very High
Recurrence 1 98.56 Very High Very High Very High
Alcohol Addiction 8 98.54 Very High Very High Very High
Urological Neuroanatomy 2 98.36 Very High Very High Very High
Sprains And Strains 128 97.56 Very High Very High Very High
Targeted Disruption 240 95.80 Very High Very High Very High
Depression 33 95.60 Very High Very High Very High
Disorders Of The Lacrimal System 1 89.92 High High
Weight Loss 1 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The simplest interpretation of our finding that loss of CRFR1 impairs certain aspects of maternal care (nursing and licking and grooming of pups) is that a certain amount of CRF tone acting on CRFR1 is required for full maternal behavior expression.
Negative_regulation (loss) of CRFR1
1) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.37 Pain Relevance 0.10
Thus, for both maternal and intermale aggression, loss of CRFR1 alters the final form of aggression in the same way.
Negative_regulation (loss) of CRFR1 associated with aggression
2) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.73 Pain Relevance 0.07
The lack of difference between genotype in pup retrieval suggests the loss of the CRFR1 gene could specifically affect more passive rather than active behaviors.
Negative_regulation (loss) of CRFR1 gene
3) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.15 Pain Relevance 0
The aim of this study was to examine whether or how loss of CRFR1 affected a range of maternal behaviors, including maternal defense.
Spec (whether) Negative_regulation (loss) of CRFR1
4) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.72 Pain Relevance 0
Hence, with tone too low (loss of CRFR1 gene) or too high, maternal care is impaired.
Negative_regulation (loss) of CRFR1 gene
5) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.33 Pain Relevance 0.09
Because CRF and its related peptides, Ucn 1 and 3, can activate CRFR2 [14,20-22], it is possible that increased activation of CRFR2 compensates for the loss of CRFR1 and contributes to alterations in maternal care.
Negative_regulation (loss) of CRFR1
6) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.14 Pain Relevance 0.07
Why this type of attack would be altered with loss of the CRFR1 gene is unclear, but alteration in stress reactivity or glucocorticoid levels could be involved [35].
Negative_regulation (loss) of CRFR1 gene associated with stress
7) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.75 Pain Relevance 0.08
In other words, the loss of CRFR1 or the use of a CRF receptor antagonist might represent a floor effect whereby further lowering already low levels of CRF neurotransmission does not alter behavior [4].
Negative_regulation (loss) of CRFR1 associated with antagonist
8) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 1.07 Pain Relevance 0.18
This finding suggests that the loss of CRFR1 may alter the final output of aggression.
Negative_regulation (loss) of CRFR1 associated with aggression
9) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.82 Pain Relevance 0.06
Naltrexone-induced morphine withdrawal resulted in down-regulation of CRF-R1 mRNA in several brain regions, including the frontal cortex, parietal cortex, striatum, nucleus accumbens, and amygdala, but not in the hypothalamus or periaqueductal gray.
Negative_regulation (down-regulation) of CRF-R1 mRNA in hypothalamus associated with nucleus accumbens, urological neuroanatomy, central grey, amygdala, withdrawal and morphine
10) Confidence 0.47 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617121 Disease Relevance 0.44 Pain Relevance 1.21
Because inbred strains show overall decreased fecundity in terms of litter size and reproduction rate relative to outbred mice, we examined the loss of the CRFR1 gene in a mixed inbred/outbred background.
Spec (examined) Negative_regulation (loss) of CRFR1 gene associated with sprains and strains
11) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.64 Pain Relevance 0
Future studies using glucocorticoid replacement, cross fostering of pups, and spatial and temporal inactivation of CRFR1 activity will be required to elucidate the basis of the maternal alterations.
Negative_regulation (inactivation) of CRFR1
12) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.46 Pain Relevance 0.07
However, if some levels of CRF acting on CRFR1 are necessary for maternal responding, it would be expected that certain behaviors would be impaired by the loss of the CRFR1 gene.
Negative_regulation (loss) of CRFR1 gene
13) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.30 Pain Relevance 0
Because the loss of CRFR1 alters both central signaling and glucocorticoid production, this study provides a detailed maternal profile of the CRFR1-/- mice, but does not examine where or how the phenotype can be rescued.
Negative_regulation (loss) of CRFR1
14) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.37 Pain Relevance 0
Certain other maternal behaviors were unaffected by the loss of CRFR1 (and nest building was even enhanced), so this receptor does not appear necessary for full expression of all maternal behaviors.
Negative_regulation (loss) of CRFR1
15) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.25 Pain Relevance 0
Where and how loss of CRFR1 contributes to behavioral alterations is not known, but one possible site is MPOM as was suggested by Egr-1 expression differences between genotype.


Negative_regulation (loss) of CRFR1
16) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.39 Pain Relevance 0
Although accumulating evidence links CRF and it primary receptor to maternal care, no study to date has examined in detail how loss of the CRFR1 gene affects maternal responding and aggression.
Spec (examined) Negative_regulation (loss) of CRFR1 gene associated with aggression
17) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.78 Pain Relevance 0.03
Chromaffin cell function and structure is impaired in corticotropin-releasing hormone receptor type 1-null mice.
Negative_regulation (impaired) of corticotropin-releasing hormone receptor type 1-null in Chromaffin cell associated with enkephalin
18) Confidence 0.38 Published 2002 Journal Mol. Psychiatry Section Title Doc Link 12399950 Disease Relevance 0.18 Pain Relevance 0.30
Disruption of CRF1 activation reduces negative affective states of opiate and alcohol withdrawal (Contarino and Papaleo, 2005; Gilpin et al., 2008), and pharmacological inhibition of CRF1 suppresses stress-mediated alcohol relapse in rats genetically selected for high alcohol preference (Valdez and Koob, 2004; Hansson et al., 2006).
Negative_regulation (inhibition) of CRF1 associated with stress, opiate, withdrawal, recurrence and alcohol
19) Confidence 0.26 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.44 Pain Relevance 0.55
The CRF receptor antagonist, alpha-helical CRF9-41 (ahCRF; 250 or 500 ng), injected icv concurrently with CRF blocked CRF-induced locomotor activity.
Negative_regulation (antagonist) of CRF receptor associated with eae and antagonist
20) Confidence 0.05 Published 1991 Journal Horm Behav Section Abstract Doc Link 1646155 Disease Relevance 0.14 Pain Relevance 0.54

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