INT123880

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
spinal 2
neurons 2
oligodendrocytes 2
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 8 100.00 Very High Very High Very High
agonist 3 99.96 Very High Very High Very High
Glutamate 8 99.52 Very High Very High Very High
Spinal sensitization 3 99.20 Very High Very High Very High
antagonist 4 97.60 Very High Very High Very High
Pain 4 96.88 Very High Very High Very High
Dopamine 1 95.88 Very High Very High Very High
tetrodotoxin 4 90.68 High High
nMDA receptor antagonist 2 89.96 High High
gABA 1 82.00 Quite High
Disease Link Frequency Relevance Heat
Death 76 98.32 Very High Very High Very High
Pain 2 96.88 Very High Very High Very High
Neuropathic Pain 5 69.56 Quite High
Demyelinating Disease 85 13.84 Low Low
Multiple Sclerosis 32 13.36 Low Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Central Nervous System Disease 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that spinal sensitization in the thermal stimulus model does not involve CaMKIIalpha activation or AMPA GLUR1 receptor phosphorylation, and differs from that occurring in NMDAr-dependent pain states.
Neg (not) Positive_regulation (involve) of Positive_regulation (activation) of GLUR1 in spinal associated with pain and spinal sensitization
1) Confidence 0.15 Published 2005 Journal Pain Section Abstract Doc Link 16150547 Disease Relevance 0.36 Pain Relevance 0.50
Ca(2+) levels within ES cell-derived neurons increased in response to glutamate receptor agonists l-glutamate, AMPA, N-methyl-d-aspartate (NMDA) and kainic acid and to acetylcholine, ATP and dopamine.
Positive_regulation (increased) of Positive_regulation (response) of glutamate receptor in neurons associated with dopamine, glutamate, glutamate receptor and agonist
2) Confidence 0.13 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15610154 Disease Relevance 0 Pain Relevance 0.74
In order to determine whether a similar effect of GluR activation occurs for oligodendrocytes, dispersed cultures were treated with sub lethal doses of KA and the amount of COX-2 expression examined by immunofluorescent confocal microscopy.
Spec (whether) Positive_regulation (effect) of Spec (whether) Positive_regulation (activation) of GluR in oligodendrocytes associated with glutamate receptor
3) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2873241 Disease Relevance 0.35 Pain Relevance 0.24

General Comments

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