INT123883

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 4.42
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
chondrocytes 2
joint 2
tendons 2
PSC 2
cleavage 2
Mmp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 255 100.00 Very High Very High Very High
Osteoarthritis 82 99.16 Very High Very High Very High
dorsal root ganglion 7 99.08 Very High Very High Very High
Spinal cord 85 98.36 Very High Very High Very High
pulpitis 4 95.36 Very High Very High Very High
Arthritis 30 91.56 High High
Neuropathic pain 2 87.76 High High
cytokine 7 85.36 High High
nMDA receptor 210 81.08 Quite High
Inflammation 27 77.76 Quite High
Disease Link Frequency Relevance Heat
Injury 23 99.60 Very High Very High Very High
Ulcers 14 99.36 Very High Very High Very High
Osteoarthritis 85 99.16 Very High Very High Very High
Ganglion Cysts 8 98.60 Very High Very High Very High
Tendinopathy 11 98.52 Very High Very High Very High
Duodenal Ulcer 26 97.20 Very High Very High Very High
Pulpitis 4 95.36 Very High Very High Very High
Infection 22 93.36 High High
Cadaver 4 93.32 High High
Arthritis 30 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The application of LPS to the pulp increased NOS activity, PGE(2), and MMP-3 production associated with iNOS overactivity.
Positive_regulation (increased) of Gene_expression (production) of MMP-3
1) Confidence 0.60 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.29 Pain Relevance 0.31
By reverse transcription-polymerase chain reaction, the expression levels of MMP-3 and CD163 were markedly up-regulated in paclitaxel-treated dorsal root ganglion.
Positive_regulation (up-regulated) of Gene_expression (expression) of MMP-3 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
2) Confidence 0.50 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.96 Pain Relevance 0.68
Densitometry revealed that the level of the activated MMP-3 was slightly increased upon NMDA treatment (1.54±0.13 fold, mean±SEM; n?
Positive_regulation (upon) of Gene_expression (level) of MMP-3
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.16
Densitometry revealed that the level of the activated MMP-3 was slightly increased upon NMDA treatment (1.54±0.13 fold, mean±SEM; n?
Positive_regulation (increased) of Gene_expression (level) of MMP-3
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.16
Densitometry revealed that the level of the activated MMP-3 was slightly increased upon NMDA treatment (1.54±0.13 fold, mean±SEM; n?
Positive_regulation (activated) of Gene_expression (level) of MMP-3
5) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.16
Consistent with the hypothesis that MMP-3 is involved in the cleavage of NR1 ectodomains we detected the activated forms of MMP-3 (45 and ?
Positive_regulation (cleavage) of Gene_expression (involved) of MMP-3 in cleavage
6) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.16
MMP-3 digests solubilized NR1 subunits
Positive_regulation (digests) of Gene_expression (digests) of MMP-3
7) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.22
Pilocarpine (5 x 10(-11) mol/L to 5 x 10(-9) mol/L), acting on mAChRs, triggered a negative effect on NOS activity, PGE(2), and MMP-3 production.
Positive_regulation (triggered) of Gene_expression (production) of MMP-3
8) Confidence 0.35 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.30 Pain Relevance 0.34
However, multiple authors have confirmed our findings, of increased MMP 1 and 9 as well as decreased MMP 3 expression in degenerated Achilles tendons [26-28].
Positive_regulation (increased) of Gene_expression (expression) of MMP 3 in tendons associated with metalloproteinase
9) Confidence 0.21 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.35 Pain Relevance 0.49
When comparing the histologic and molecular changes of the intraarticular and extraarticular LHB after tenotomy, Joseph et al. described increased MMP 1 and MMP 3 expression associated with histologic signs of tendinopathy [17].
Positive_regulation (increased) of Gene_expression (expression) of MMP 3 associated with metalloproteinase and tendinopathy
10) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.43 Pain Relevance 0.39
RESULTS: PDGF-BB increased PSC proliferation and migration, accompanied by elevated expression of matrix metalloproteinases (MMP)-13 and MMP-3.
Positive_regulation (elevated) of Gene_expression (expression) of MMP-3 in PSC
11) Confidence 0.18 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0
In the presence of FGF8 (100 ng/ml), production of proMMP-3 by rabbit chondrocytes was significantly induced (P = 0.0079; Figure 3a).
Positive_regulation (induced) of Gene_expression (production) of proMMP-3 in chondrocytes
12) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.15 Pain Relevance 0.12
BMA resulted in decreased COMP and increased MMP-3 and MMP-13 gene expression.
Positive_regulation (increased) of Gene_expression (expression) of MMP-3
13) Confidence 0.13 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.11
RESULTS: In all tissue specimens, MMP-3 expression was intense in the surface layer but showed less intensive staining in the deeper layers.
Positive_regulation (intense) of Gene_expression (expression) of MMP-3
14) Confidence 0.13 Published 2005 Journal J. Oral Pathol. Med. Section Body Doc Link 15610405 Disease Relevance 0.09 Pain Relevance 0
Levels of proMMP-3 are reported to increase in joint injury and OA [6].
Positive_regulation (increase) of Gene_expression (Levels) of proMMP-3 in joint associated with injury and osteoarthritis
15) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.06 Pain Relevance 0.45
This data suggests that patients with higher MMP-3 expression may have lower ulcer risk, but the reasons remain uncertain.
Positive_regulation (higher) of Gene_expression (expression) of MMP-3 associated with ulcers
16) Confidence 0.05 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2928200 Disease Relevance 0.79 Pain Relevance 0
CONCLUSION: These findings indicate that IL-1beta up-regulates Wnt-5A, and the activation of Wnt-5A signaling induces the expression of MMP-1, MMP-3, MMP-9, and MMP-13 via the JNK signaling pathway in rabbit TMJ condylar chondrocytes.
Positive_regulation (induces) of Gene_expression (expression) of MMP-3 in TMJ
17) Confidence 0.02 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19714632 Disease Relevance 0 Pain Relevance 0

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