INT123890

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.03
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl2) extracellular region (Cxcl2)
Anatomy Link Frequency
Macrophage 2
inflammatory macrophage 2
neutrophil 2
alveolar macrophages 1
bowel 1
Cxcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 152 100.00 Very High Very High Very High
cytokine 100 100.00 Very High Very High Very High
chemokine 40 100.00 Very High Very High Very High
ischemia 35 100.00 Very High Very High Very High
Morphine 23 99.62 Very High Very High Very High
Inflammatory stimuli 5 99.48 Very High Very High Very High
fibrosis 62 69.68 Quite High
rheumatoid arthritis 52 59.88 Quite High
Arthritis 5 36.36 Quite Low
diclofenac 1 15.44 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 181 100.00 Very High Very High Very High
Cv General 4 Under Development 11 100.00 Very High Very High Very High
Lung Injury 32 99.92 Very High Very High Very High
Bacterial Meningitis 14 99.84 Very High Very High Very High
Injury 38 99.62 Very High Very High Very High
Infection 34 99.44 Very High Very High Very High
Apoptosis 76 98.72 Very High Very High Very High
Hyperoxia 8 98.64 Very High Very High Very High
Stroke 81 95.84 Very High Very High Very High
Acne 164 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early local radiation-induced tissue injury of small bowel in this refined rodent model shows a progressive, infiltration of inflammatory cells into tissues probably mediated by the release of MIP-2 and a dose related increase of apoptosis.
Localization (release) of MIP-2 in bowel associated with inflammation, injury and apoptosis
1) Confidence 0.67 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.76 Pain Relevance 0.09
Macrophage inflammatory protein-2 (MIP-2) is a CXC chemokine and its secretion enhanced by inflammatory stimuli.
Localization (secretion) of MIP-2 in Macrophage associated with chemokine, inflammation and inflammatory stimuli
2) Confidence 0.67 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.55 Pain Relevance 0.31
To explore the chemoattractants in VILI we measured MIP-2 and IP-10, involved in angiogenetic activity and angiostatic activity, respectively (Figure 1c,d).
Localization (measured) of MIP-2 associated with lung injury
3) Confidence 0.40 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.48 Pain Relevance 0.19
Morphine treatment reduced MIP-2 release in pneumococci stimulated alveolar macrophages.
Localization (release) of MIP-2 in alveolar macrophages associated with bacterial meningitis and morphine
4) Confidence 0.25 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.80 Pain Relevance 0.48
Using an in vitro alveolar macrophages and lung epithelial cells infection model, we show significant release of MIP-2 from alveolar macrophages, but not from lung epithelial cells, following 4 h of exposure of cells to pneumococci infection.
Localization (release) of MIP-2 in lung associated with bacterial meningitis and infection
5) Confidence 0.25 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.76 Pain Relevance 0.39
The authors demonstrated that hyperoxia enhanced large Vt-induced epithelial cell injury by stimulation of MIP-2 release with the consequent increase in pulmonary neutrophil sequestration.
Localization (release) of MIP-2 in neutrophil associated with injury and hyperoxia
6) Confidence 0.21 Published 2008 Journal Crit Care Section Body Doc Link PMC2592724 Disease Relevance 1.00 Pain Relevance 0.03
The decreased synthesis of MIP-2 and inflammatory cytokines coupled with the decreased release of galectin-3 result in reduced migration of neutrophils to the site of infection, thereby increasing susceptibility to S. pneumoniae infection after morphine treatment.
Localization (release) of MIP-2 in neutrophils associated with inflammation, infection, morphine and cytokine
7) Confidence 0.16 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15611267 Disease Relevance 0.77 Pain Relevance 0.87
Furthermore, the sialidase-immunized mice provided protective immunity against P. acnes in vivo as this treatment blocked an increase in ear thickness and release of pro-inflammatory macrophage inflammatory protein (MIP-2) cytokine.


Localization (release) of MIP-2 in inflammatory macrophage associated with inflammation and cytokine
8) Confidence 0.10 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2212713 Disease Relevance 0.85 Pain Relevance 0.15
Furthermore, the sialidase-immunized mice provided protective immunity against P. acnes in vivo as this treatment blocked an increase in ear thickness and release of pro-inflammatory macrophage inflammatory protein (MIP-2) cytokine.


Localization (release) of macrophage inflammatory protein in inflammatory macrophage associated with inflammation and cytokine
9) Confidence 0.10 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2212713 Disease Relevance 0.85 Pain Relevance 0.15
stimulate the production and release of specific chemokines after cerebral ischemia, such as CINC (cytokine induced neutrophil chemoattractant), MCP-1 (monocyte chemoattractant 1), fractalkine, MRF-1 (microglial response factor-1) and MIP-1 (macrophage inflammatory protein 1).
Localization (release) of macrophage inflammatory protein 1 in macrophage associated with chemokine, inflammation, cv general 4 under development, ischemia and cytokine
10) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.64 Pain Relevance 0.64
Among them are macrophage inflammatory protein (MIP), MCP, CCL5 (also known as RANTES [regulated on activation, normal T-cell expressed and secreted]) and IL-8.
Localization (secreted) of macrophage inflammatory protein in T-cell associated with inflammation
11) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.56 Pain Relevance 0.35

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