INT123899

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CYP3A4, UGT2B7) lipid metabolic process (CYP3A4, UGT2B7) small molecule metabolic process (CYP3A4)
oxidoreductase activity (CYP3A4) enzyme binding (CYP3A4) cytoplasm (CYP3A4)
Anatomy Link Frequency
liver 1
CYP3A4 (Homo sapiens)
UGT2B7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 21 100.00 Very High Very High Very High

|}

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strongly suggest that 1) the glucuronidation activity of UGT2B7 toward morphine is specifically modulated by interaction with CYP3A4 in microsomal membranes and that 2) CYP3A4 alters UGT2B7 regioselectivity so that the ratio of morphine activation/detoxication is increased.
CYP3A4 Binding (interaction) of UGT2B7 associated with morphine
1) Confidence 0.52 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15611481 Disease Relevance 0 Pain Relevance 0.56
Immunoprecipitation of UGT from solubilized human liver microsomes resulted in coprecipitation of CYP3A4 with UGT2B7.
CYP3A4 Binding (coprecipitation) of UGT2B7 in liver
2) Confidence 0.40 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15611481 Disease Relevance 0 Pain Relevance 0.44
The protein-protein interaction between CYP3A4 and UGT2B7 was further confirmed by overlay assay using glutathione S-transferase-CYP3A4 fusion protein.
CYP3A4 Binding (interaction) of UGT2B7
3) Confidence 0.39 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15611481 Disease Relevance 0 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox