INT123903

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.71
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATXN3) peptidase activity (ATXN3) cell death (ATXN3)
nucleus (ATXN3) cytoplasm (ATXN3)
Anatomy Link Frequency
spinal 1
ATXN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 12 100.00 Very High Very High Very High
Calcium channel 7 100.00 Very High Very High Very High
hyperexcitability 1 92.24 High High
depression 1 85.92 High High
Pain 4 78.40 Quite High
headache 3 73.12 Quite High
qutenza 4 71.08 Quite High
cva 4 60.76 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 12 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 12 100.00 Very High Very High Very High
Ataxia 8 100.00 Very High Very High Very High
Targeted Disruption 46 99.78 Very High Very High Very High
Disease 73 99.18 Very High Very High Very High
Neurodegenerative Disease 4 98.16 Very High Very High Very High
Cerebellar Diseases 1 96.68 Very High Very High Very High
Migraine With Aura 2 95.24 Very High Very High Very High
Frailty 2 93.88 High High
Dengue Hemorrhagic Fever 16 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Q71-B transgenic mice [23] express the human MJD1a splice isoform as a cDNA driven by the prion promoter, and thus only exhibit alternative splicing of endogenous ataxin-3.
Gene_expression (express) of MJD associated with targeted disruption
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.55 Pain Relevance 0.06
Briefly, Q28 ataxin-3 was amplified using MJD.Nter.F#722 (see below) and the primer hMJD2UIM-R1N (5?
Gene_expression (using) of MJD
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.27 Pain Relevance 0.08
Transcript and protein expression of AT3 was tissue-specific and developmentally regulated.
Gene_expression (expression) of AT3
3) Confidence 0.27 Published 2005 Journal Plant J. Section Abstract Doc Link 15918882 Disease Relevance 0 Pain Relevance 0.20
[Molecular physiopathology of the spinocerebellar ataxia type 6 (SCA6)].
Gene_expression (physiopathology) of SCA6 associated with spinocerebellar ataxia type 2
4) Confidence 0.21 Published 2004 Journal Rev. Invest. Clin. Section Title Doc Link 15612520 Disease Relevance 1.23 Pain Relevance 0.15
[Molecular physiopathology of the spinocerebellar ataxia type 6 (SCA6)].
Gene_expression (physiopathology) of spinocerebellar ataxia type 6 associated with spinocerebellar ataxia type 2
5) Confidence 0.18 Published 2004 Journal Rev. Invest. Clin. Section Title Doc Link 15612520 Disease Relevance 1.23 Pain Relevance 0.15
The impact of the disease is very heterogeneous in the State: the city of São José do Rio Preto – included in our study - reported 12% (9.331) of the occurrences in the State having only 1% of its population [11].
Gene_expression (city) of Jos associated with disease
6) Confidence 0.17 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2682200 Disease Relevance 1.68 Pain Relevance 0.14
DENV-3 was first isolated in São José do Rio Preto in January 2006.
Gene_expression (do) of Jos
7) Confidence 0.17 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2682200 Disease Relevance 0.08 Pain Relevance 0
Purkinje cells express calcium channels that are related to the pathophysiology of both inherited forms of migraine and primary ataxias, mostly spinal cerebellar ataxia type 6 (SCA-6) and episodic ataxia type 2 (EA-2).
Gene_expression (express) of spinal cerebellar ataxia type 6 in spinal associated with ataxia, migraine and calcium channel
8) Confidence 0.03 Published 2007 Journal Headache Section Abstract Doc Link 17578530 Disease Relevance 1.67 Pain Relevance 1.08

General Comments

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