INT123908

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.50
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQB1) Golgi apparatus (HLA-DQB1) endoplasmic reticulum (HLA-DQB1)
plasma membrane (HLA-DQB1) intracellular (HLA-DQB1)
Anatomy Link Frequency
macrophages 2
neuronal 2
monocytes 2
B lymphocytes 2
platelet 2
HLA-DQB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 7 99.12 Very High Very High Very High
Inflammation 394 97.72 Very High Very High Very High
Neuritis 9 95.52 Very High Very High Very High
cytokine 64 71.52 Quite High
Inflammatory response 36 71.44 Quite High
Cluster headache 8 50.00 Quite Low
Spinal cord 48 13.56 Low Low
fibrosis 40 5.00 Very Low Very Low Very Low
nud 32 5.00 Very Low Very Low Very Low
anesthesia 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Idiopathic Thrombocytopenic Purpura 42 100.00 Very High Very High Very High
Demyelinating Disease 7 99.12 Very High Very High Very High
INFLAMMATION 436 97.72 Very High Very High Very High
Optic Neuritis 9 95.52 Very High Very High Very High
Thrombosis Related Under Development 2 84.68 Quite High
Infection 186 78.96 Quite High
Spontaneous Remission 2 74.96 Quite High
Viral Infection 2 72.84 Quite High
Thrombocytopenia 2 65.72 Quite High
Autoimmune Disease 10 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In DQB1, the frequency of DQB1*0602 increased significantly in the MS patients.
Positive_regulation (increased) of DQB1 associated with multiple sclerosis
1) Confidence 0.21 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 15613143 Disease Relevance 1.09 Pain Relevance 0.92
BIRC1 (neuronal apoptosis inhibitory protein), CREB5, HLA-DQA1, and HLA-DQB1 were upregulated in patients compared to controls.
Positive_regulation (upregulated) of HLA-DQB1 in neuronal
2) Confidence 0.17 Published 2006 Journal Headache Section Body Doc Link 17115985 Disease Relevance 0 Pain Relevance 0
BIRC1 (neuronal apoptosis inhibitory protein), CREB5, HLA-DQA1, and HLA-DQB1 were upregulated in patients compared to controls.
Positive_regulation (upregulated) of HLA-DQB1 in neuronal
3) Confidence 0.13 Published 2006 Journal Headache Section Body Doc Link 17115985 Disease Relevance 0 Pain Relevance 0
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (up) of HLA-DQB in B lymphocytes associated with inflammation
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.73 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (regulation) of HLA-DQB in B lymphocytes associated with inflammation
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.68 Pain Relevance 0.35
According to another report by the same authors,172 the frequencies of HLA-DRB 111, HLA-DRB 114, and HLA-DQB 103 as host factors were high in H. pylori-positive ITP, while the frequency of HLA-DRB 103 as a host factor was higher in the H. pylori-negative ITP group than in the H. pylori-positive ITP group, and HLA-DQB 103 showed favorable platelet reactivity after eradication therapy in H. pylori-positive ITP.172 Inaba et al.173 administered H. pylori eradication therapy to 35 patients with chronic ITP (25 H. pylori-positive ITP patients and 10 H. pylori-negative ITP patients), and succeeded in eradicating the bacteria in all of the patients with H. pylori-positive ITP.
Positive_regulation (high) of HLA-DQB 103 in platelet associated with idiopathic thrombocytopenic purpura
6) Confidence 0.05 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780612 Disease Relevance 1.81 Pain Relevance 0
According to another report by the same authors,172 the frequencies of HLA-DRB 111, HLA-DRB 114, and HLA-DQB 103 as host factors were high in H. pylori-positive ITP, while the frequency of HLA-DRB 103 as a host factor was higher in the H. pylori-negative ITP group than in the H. pylori-positive ITP group, and HLA-DQB 103 showed favorable platelet reactivity after eradication therapy in H. pylori-positive ITP.172 Inaba et al.173 administered H. pylori eradication therapy to 35 patients with chronic ITP (25 H. pylori-positive ITP patients and 10 H. pylori-negative ITP patients), and succeeded in eradicating the bacteria in all of the patients with H. pylori-positive ITP.
Positive_regulation (high) of HLA-DQB 103 in platelet associated with idiopathic thrombocytopenic purpura
7) Confidence 0.05 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780612 Disease Relevance 1.94 Pain Relevance 0
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (regulation) of HLA-DQB in T lymphocytes associated with inflammation
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.68 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (regulation) of HLA-DQB in macrophages associated with inflammation
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.68 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (up) of HLA-DQB in macrophages associated with inflammation
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.73 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (up) of HLA-DQB in monocytes associated with inflammation
11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.73 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (regulation) of HLA-DQB in monocytes associated with inflammation
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.68 Pain Relevance 0.35
The high up-regulation of CD74, HLA-DQB, and THY1 (Table 1, Figure 1c) suggests infiltration of inflammation-related cells, such as T lymphocytes and B lymphocytes, monocytes, and macrophages.
Positive_regulation (up) of HLA-DQB in T lymphocytes associated with inflammation
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.73 Pain Relevance 0.35

General Comments

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