INT123910

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.81
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CXCL16) extracellular region (CXCL16) plasma membrane (CXCL16)
Anatomy Link Frequency
macrophages 2
endothelial cells 1
T cells 1
CXCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 68 100.00 Very High Very High Very High
mu opioid receptor 2 99.96 Very High Very High Very High
Neuritis 9 97.96 Very High Very High Very High
qutenza 8 95.80 Very High Very High Very High
Multiple sclerosis 89 94.92 High High
Osteoarthritis 45 94.32 High High
cytokine 38 92.36 High High
Inflammation 86 91.96 High High
Hyperalgesia 10 90.56 High High
Potency 2 89.72 High High
Disease Link Frequency Relevance Heat
Sarcoidosis 80 99.68 Very High Very High Very High
Optic Neuritis 9 97.96 Very High Very High Very High
Synovitis 2 96.48 Very High Very High Very High
Syndrome 42 96.36 Very High Very High Very High
Adhesions 8 96.00 Very High Very High Very High
Multiple Sclerosis 93 94.92 High High
Frailty 48 94.32 High High
Contact Dermatitis 28 92.60 High High
INFLAMMATION 100 91.96 High High
Hyperalgesia 11 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to our negative findings regarding macrophage polarization, previous studies have demonstrated higher expression of the M1 markers CXCL10 [6], CXCL11 [7] and CXCL16 [8] in sarcoidosis patients compared to healthy subjects.
Gene_expression (expression) of CXCL16 in macrophage associated with sarcoidosis
1) Confidence 0.49 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.36 Pain Relevance 0.11
Using real-time PCR, the relative gene expression of IL-10, IL-12p35, IL-12p40, IL-23p19, CCR2, CCR7, iNOS, CXCL10, CXCL11, CXCL16, CCL18, CCL20, CD80, and CD86, and innate immune receptors TLR2, TLR4, and TLR9, was quantified in sorted AMs, and for selected genes in total BAL cells, while IL-17A was quantified in T cells.


Gene_expression (expression) of CXCL16 in T cells
2) Confidence 0.44 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2939603 Disease Relevance 0.73 Pain Relevance 0.04
In addition to the expression of E-selectin, CCL17, CXCL16, CX3CL1, and increased numbers of integrin ligands [33-35], we show here for the first time a very early production of CS-1 fibronectin by activated endothelial cells in patients with ACD.
Gene_expression (expression) of CXCL16 in endothelial cells associated with contact dermatitis
3) Confidence 0.38 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.09 Pain Relevance 0
The study of Kang et al [145] documents augmented production of CXCL16, a regulator of T cell migration, by macrophages due to presence of LPA (or S1P) following stimulation by LPS, of interest in MS because of parallels with S1P.
Gene_expression (production) of CXCL16 in macrophages associated with multiple sclerosis
4) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.40 Pain Relevance 0.31
Furthermore, CCL2, CCL3 (MIP-1a), CCL5 and CXC chemokine ligand 8 also desensitize mu-opioid receptors.
Gene_expression (desensitize) of CXC chemokine ligand 8 associated with chemokine and mu opioid receptor
5) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.04 Pain Relevance 1.37
HLA-B44, B16 and B38 alleles were not present in CDMS patients.
Neg (not) Gene_expression (present) of B16
6) Confidence 0.09 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 15613143 Disease Relevance 1.18 Pain Relevance 0.98

General Comments

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