INT12392

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Context Info
Confidence 0.36
First Reported 1981
Last Reported 2010
Negated 5
Speculated 7
Reported most in Abstract
Documents 45
Total Number 53
Disease Relevance 7.57
Pain Relevance 25.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
neurons 6
peritoneum 2
skin 2
synapses 2
body 2
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1053 100.00 Very High Very High Very High
agonist 226 100.00 Very High Very High Very High
Enkephalin 175 100.00 Very High Very High Very High
antagonist 121 100.00 Very High Very High Very High
dopamine receptor 73 100.00 Very High Very High Very High
narcan 37 100.00 Very High Very High Very High
Opioid 33 100.00 Very High Very High Very High
opioid receptor 15 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
MU agonist 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Eating Disorder 8 100.00 Very High Very High Very High
Diabetes Mellitus 181 99.82 Very High Very High Very High
Targeted Disruption 14 98.70 Very High Very High Very High
Drug Induced Neurotoxicity 3 98.12 Very High Very High Very High
Stress 39 95.84 Very High Very High Very High
Urological Neuroanatomy 7 95.72 Very High Very High Very High
Injury 33 95.56 Very High Very High Very High
Recurrence 5 95.36 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 312 94.72 High High
Erectile Dysfunction 4 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, no changes were observed in the amounts of D1, D2, D3 mRNA, or D2 heteronuclear RNA (hnRNA) in the striatum or in the levels of D2 mRNA and hnRNA in the substantia nigra and ventral tegmental area.
Regulation (observed) of D2 in ventral associated with ventral tegmentum and substantia nigra
1) Confidence 0.36 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.38
Thus, increased striatal D2 binding after haloperidol treatment may not be the result of altered D2 gene activity in the striatum or midbrain, but could result from an increase in D2 mRNA in cingulate corticostriatal neurons and/or a longer half-life for the D2 receptor protein in striatal neurons.
Regulation (altered) of D2 in neurons associated with midbrain
2) Confidence 0.36 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.37
The current studies were aimed at better defining the effects of food restriction on D2 and D3 receptor function by assessing the capacity of N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole) to induce yawning, penile erection (PE), hypothermia, and locomotor activity in free-fed and food-restricted rats.
Regulation (effects) of D2 associated with hypothermia, erectile dysfunction, eae and eating disorder
3) Confidence 0.24 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305018 Disease Relevance 0.96 Pain Relevance 0.56
This study examines the effects of haloperidol on dopaminoceptive striatal neurons, as well as dopamine D2 containing striatal inputs.
Spec (examines) Regulation (effects) of D2 in neurons associated with dopamine
4) Confidence 0.19 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.32
The D1 and D2 agonists, (+/-)-1-phenyl-2,3,4, 5-tetrahydro-(1H)-3-benzazepine-7,8-diol (SKF-38393) and quinpirole, respectively, and the D1 and D2 antagonists, R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4, 5-tetrahydro-1H-3-benzazepine (SCH-23390) and raclopride, respectively, did not alter the release of serotonin in the median raphe nucleus.
Regulation (alter) of D2 in raphe nucleus associated with antagonist, agonist, raphe and serotonin
5) Confidence 0.18 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10383619 Disease Relevance 0 Pain Relevance 0.81
The D1 and D2 agonists, (+/-)-1-phenyl-2,3,4, 5-tetrahydro-(1H)-3-benzazepine-7,8-diol (SKF-38393) and quinpirole, respectively, and the D1 and D2 antagonists, R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4, 5-tetrahydro-1H-3-benzazepine (SCH-23390) and raclopride, respectively, did not alter the release of serotonin in the median raphe nucleus.
Regulation (alter) of D2 in raphe nucleus associated with antagonist, agonist, raphe and serotonin
6) Confidence 0.18 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10383619 Disease Relevance 0 Pain Relevance 0.83
DA uptake sites, D1 and D2 receptors, D2 and preproenkephalin mRNAs and Fos immunoreactivity in rat striatal subregions after partial dopaminergic degeneration.
Regulation (immunoreactivity) of D2 associated with enkephalin
7) Confidence 0.17 Published 1996 Journal Eur. J. Neurosci. Section Title Doc Link 8996800 Disease Relevance 0 Pain Relevance 0.28
DA uptake sites, D1 and D2 receptors, D2 and preproenkephalin mRNAs and Fos immunoreactivity in rat striatal subregions after partial dopaminergic degeneration.
Regulation (immunoreactivity) of D2 associated with enkephalin
8) Confidence 0.17 Published 1996 Journal Eur. J. Neurosci. Section Title Doc Link 8996800 Disease Relevance 0 Pain Relevance 0.28
D1 and D2 receptor regulation of preproenkephalin and preprodynorphin mRNA in rat striatum following acute injection of amphetamine or methamphetamine.
Regulation (regulation) of D2 in striatum associated with enkephalin
9) Confidence 0.17 Published 1996 Journal Synapse Section Title Doc Link 8787127 Disease Relevance 0 Pain Relevance 0.23
In the present studies, we measured the effects of central administration of naloxone and the mu agonist [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO) on the ingestion of salt solutions.
Regulation (effects) of D-Ala2 associated with agonist, narcan and enkephalin
10) Confidence 0.16 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2153308 Disease Relevance 0 Pain Relevance 0.83
Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats.
Regulation (alters) of D2 associated with dopamine, mu agonist, analgesic and agonist
11) Confidence 0.15 Published 2007 Journal Psychopharmacology (Berl.) Section Title Doc Link 17619861 Disease Relevance 0 Pain Relevance 0.73
Proenkephalin and the D2-receptor mRNAs were not altered during cocaine abstinence, though proenkephalin was elevated following acute but not repeated cocaine administration.
Neg (not) Regulation (altered) of D2 associated with cocaine
12) Confidence 0.14 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602109 Disease Relevance 0 Pain Relevance 0.74
However, no changes were observed in the amounts of D1, D2, D3 mRNA, or D2 heteronuclear RNA (hnRNA) in the striatum or in the levels of D2 mRNA and hnRNA in the substantia nigra and ventral tegmental area.
Regulation (observed) of D2 in substantia nigra associated with ventral tegmentum and substantia nigra
13) Confidence 0.12 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.38
An incision was performed 2 cm below the sternum; affecting skin and muscle and peritoneum [D1 (9), D2 (10), P (10) or E (10)].
Regulation (affecting) of D2 in skin
14) Confidence 0.11 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2582036 Disease Relevance 0.25 Pain Relevance 0.06
Bilateral adrenalectomy performed on E resulted in higher testosterone levels than in sham operated group, while significantly differences in rats treated on D1, D2 or P, were not observed.


Regulation (treated) of D2
15) Confidence 0.11 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2582036 Disease Relevance 0 Pain Relevance 0
A bilateral incision (left and right side) was performed 2 cm below the last rib; affecting skin, muscle, and peritoneum [D1 (11), D2 (10), P (11) or E (10)].
Regulation (affecting) of D2 in muscle
16) Confidence 0.11 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2582036 Disease Relevance 0.17 Pain Relevance 0.07
D1- and D2-dopamine receptor-mediated regulation of immediate early gene levels in identified populations of neurons in the striatum was examined with quantitative in situ hybridization histochemical techniques.
Regulation (regulation) of D2 in neurons associated with dopamine receptor
17) Confidence 0.11 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 8613751 Disease Relevance 0 Pain Relevance 0.22
In order to investigate the relative role of central delta- and mu-opioid receptors in behavior, the effects of (D-Ala2)deltorphin II, a natural delta-opioid peptide, and PL017, a beta-casomorphin derivative specific for mu receptors, were compared after local intracerebral and intraventricular administration.
Regulation (effects) of D-Ala2 associated with mu opioid receptor and opioid
18) Confidence 0.08 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1646295 Disease Relevance 0 Pain Relevance 0.26
The effects of a single dose of naloxone and of [D-Met2,Pro5]enkephalinamide on the DNA synthesis in the uterus of 7, 14 and 21-day-old rat were studied.
Regulation (effects) of D-Met2 in uterus associated with narcan
19) Confidence 0.07 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566160 Disease Relevance 0 Pain Relevance 0.15
Most MSN connections showed both D1 and D2 modulation, consistent with near complete overlap in the expression of D1- and D2-like receptors on individual MSNs.
Spec (like) Regulation (modulation) of D2
20) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.96

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