INT123924

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.11
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) plasma membrane (Cd44) nucleus (Cd44)
protein complex (Cd44)
Anatomy Link Frequency
monocytes 4
spinal cord 2
Cd44 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 100.00 Very High Very High Very High
Neuritis 8 97.96 Very High Very High Very High
Inflammation 37 97.72 Very High Very High Very High
Sciatic nerve 1 85.40 High High
Central nervous system 1 77.20 Quite High
Inflammatory response 4 57.64 Quite High
cytokine 40 53.84 Quite High
Inflammatory mediators 2 35.68 Quite Low
Analgesic 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 8 97.96 Very High Very High Very High
INFLAMMATION 43 97.72 Very High Very High Very High
Immunization 1 79.48 Quite High
Infection 8 58.72 Quite High
Weight Loss 2 56.24 Quite High
Toxicity 2 40.88 Quite Low
Foreign Bodies 6 39.60 Quite Low
Cancer 8 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Communicable Diseases 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of CD44, a receptor of OPN, was weak in normal spinal cord tissue and increased in the entire spinal cord parenchyma in rats with EAN, as well as in inflammatory cells.
Positive_regulation (increased) of Gene_expression (Expression) of CD44 in spinal cord associated with inflammation, neuritis and spinal cord
1) Confidence 0.46 Published 2004 Journal J. Vet. Sci. Section Abstract Doc Link 15613811 Disease Relevance 0.89 Pain Relevance 1.17
These latter cells also exhibited an enhanced potential of extravasation ability, as suggested by increased expression of CD44 on their cellular membrane [18], as well as characteristics of activated monocytes [19,20], as indicated by the higher percentage of CD25+ cells in circulating monocytes, compared to the untreated control rats.
Positive_regulation (increased) of Gene_expression (expression) of CD44 in monocytes
2) Confidence 0.22 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0.23 Pain Relevance 0.08
Cytofluorimetric analysis showed that at T15 EO treatment induced a significant increase of the expression of CD44, as well as the percentage of CD25+ cells in circulating monocytes compared to the untreated control rats, and this effect also persisted at T20, after 5 days from the end of EO administration (Fig. 6e, f).
Positive_regulation (increase) of Gene_expression (expression) of CD44 in monocytes
3) Confidence 0.22 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2374764 Disease Relevance 0 Pain Relevance 0

General Comments

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