INT123935

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (BMPR2) cytoplasm (BMPR2)
Anatomy Link Frequency
artery smooth muscle 1
BMPR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 4 80.88 Quite High
Angina 1 77.56 Quite High
Serotonin 2 62.40 Quite High
potassium channel 1 48.80 Quite Low
Inflammation 8 47.80 Quite Low
cytokine 3 47.28 Quite Low
alcohol 3 13.84 Low Low
aspirin 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 8 96.96 Very High Very High Very High
Congenital Anomalies 2 91.60 High High
Shock 4 87.96 High High
Aging 58 83.00 Quite High
Cancer 2 82.16 Quite High
Necrosis 4 81.68 Quite High
Syncope 2 78.04 Quite High
Angina 1 77.56 Quite High
Fatigue 1 77.08 Quite High
Dyspnea 1 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Severe pulmonary hypertension is associated with an increased expression of the angiogenic factor, angiopoietin-1, which shuts off the expression of BMPR1A, a transmembrane protein necessary for BMPR2 signalling, and thereby causes pulmonary artery smooth muscle cell proliferation.
Positive_regulation (necessary) of BMPR2 in artery smooth muscle associated with pulmonary hypertension
1) Confidence 0.26 Published 2004 Journal Bull. Mem. Acad. R. Med. Belg. Section Abstract Doc Link 15615096 Disease Relevance 1.05 Pain Relevance 0.14
We performed a set of replicate readings, obtained by measuring BMR of 8 elderly patients (5 male), of mean age (SD) 75 years [8], on two consecutive days after adjusting for meal times (after 4 hours), medications and severity of illness (CRP).
Positive_regulation (measuring) of BMR
2) Confidence 0.22 Published 2006 Journal Nutr J Section Body Doc Link PMC1448191 Disease Relevance 0.07 Pain Relevance 0
Significantly upregulated genes included bone morphogenetic protein receptor, type II (serine/threonine kinase), and protein tyrosine phosphatase, receptor type A.
Positive_regulation (upregulated) of bone morphogenetic protein receptor
3) Confidence 0.18 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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