INT123962

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.82
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.08
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
smooth muscle 2
muscle 2
myocytes 1
heart 1
Hspb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1 98.02 Very High Very High Very High
Snapping jaw 7 86.80 High High
Morphine 2 83.84 Quite High
Enkephalin 1 74.92 Quite High
Dismenorea 6 74.88 Quite High
isoflurane 2 62.80 Quite High
COX-2 inhibitor 1 56.60 Quite High
Angina 3 36.76 Quite Low
agonist 1 7.92 Low Low
ischemia 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 20 99.72 Very High Very High Very High
Temporomandibular Joint Syndrome 7 78.96 Quite High
Dysmenorrhea 6 74.88 Quite High
Aging 18 70.64 Quite High
Stress 5 53.12 Quite High
Infarction 2 38.00 Quite Low
Cv General 3 Under Development 3 36.76 Quite Low
Myocardial Infarction 5 17.76 Low Low
Cv Unclassified Under Development 24 5.00 Very Low Very Low Very Low
Reperfusion Injury 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since phosphorylation of Hsp27 has been reported to be a prerequisite for smooth muscle contraction, we examined the temporal and spatial expression of Ser-15 phosphorylated Hsp27.
Phosphorylation (phosphorylation) of Hsp27 in smooth muscle
1) Confidence 0.82 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.31 Pain Relevance 0.07
Immunocytochemical analysis of Ser-15 phosphorylated Hsp27 expression in situ demonstrated that phosphorylated Hsp27 in circular muscle became detectable in peri-nuclear and membrane regions on days 19 to 22, but was primarily restricted to the cytoplasm on days 23 to PP.
Phosphorylation (phosphorylated) of Hsp27 in muscle
2) Confidence 0.82 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.25 Pain Relevance 0.06
In contrast, phosphorylated Hsp27 in longitudinal muscle was primarily detected in myocyte membranes on days 15 to 22, and then also became detectable in the cytoplasm of myocytes on days 23 and PP.
Phosphorylation (phosphorylated) of Hsp27 in myocytes
3) Confidence 0.82 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.18 Pain Relevance 0
Since phosphorylation of Hsp27 has been reported to be a prerequisite for smooth muscle contraction, we examined the temporal and spatial expression of Ser-15 phosphorylated Hsp27.
Phosphorylation (phosphorylated) of Hsp27 in smooth muscle
4) Confidence 0.82 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.29 Pain Relevance 0.07
Current observations imply the presence of the phosphorylation of Hsp25 via activated MAPKAPK-2 in the cytoplasm.
Phosphorylation (phosphorylation) of Hsp25
5) Confidence 0.79 Published 2005 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 15791578 Disease Relevance 0.33 Pain Relevance 0.37
Immunocytochemical analysis of Ser-15 phosphorylated Hsp27 expression in situ demonstrated that phosphorylated Hsp27 in circular muscle became detectable in peri-nuclear and membrane regions on days 19 to 22, but was primarily restricted to the cytoplasm on days 23 to PP.
Phosphorylation (phosphorylated) of Hsp27 in muscle
6) Confidence 0.63 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.26 Pain Relevance 0.06
Immunoblot analysis showed that the detection of Ser-15 phosphorylated Hsp27 significantly increased (P <0.05) between days 19 and 23 (active labour) inclusive, in parallel with detection of total Hsp27.
Phosphorylation (phosphorylated) of Hsp27
7) Confidence 0.55 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.28 Pain Relevance 0.07
Coupling between the opioid receptor and p38 MAPK (mitogen-activated protein kinase) was shown to be lost in the aged mouse heart, and phosphorylation of the downstream protein HSP27 (Heat shock protein 27) was reduced [52,53].


Phosphorylation (phosphorylation) of HSP27 in heart associated with shock and opioid receptor
8) Confidence 0.28 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.17 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox