INT123963

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.39
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
myometrium 4
hepatocytes 2
Hspb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 5 96.28 Very High Very High Very High
fibrosis 1 94.64 High High
Paracetamol 1 93.28 High High
ischemia 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 26 100.00 Very High Very High Very High
Apoptosis 1 98.82 Very High Very High Very High
Dysmenorrhea 5 96.28 Very High Very High Very High
Cirrhosis 1 94.64 High High
Plasmacytoma 2 91.20 High High
Injury 1 91.20 High High
Hodgkin's Disease 1 90.52 High High
Hepatitis 2 88.84 High High
Hepatitis Virus Infection 5 83.32 Quite High
Cancer 39 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, we hypothesized that Hsp27 expression would be highly induced during late pregnancy and labour.
Positive_regulation (induced) of Gene_expression (expression) of Hsp27
1) Confidence 0.70 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.35 Pain Relevance 0.09
Small heat shock protein 27 (Hsp27) expression is highly induced in rat myometrium during late pregnancy and labour.
Positive_regulation (induced) of Gene_expression (expression) of heat shock protein 27 in myometrium associated with shock
2) Confidence 0.70 Published 2005 Journal Reproduction Section Title Doc Link 15615903 Disease Relevance 0.38 Pain Relevance 0.10
Our results demonstrate that Hsp27 expression is highly upregulated during late pregnancy and labour and suggest that Hsp27 is a potential candidate contraction-associated protein.
Positive_regulation (upregulated) of Gene_expression (expression) of Hsp27
3) Confidence 0.70 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.07 Pain Relevance 0
Small heat shock protein 27 (Hsp27) expression is highly induced in rat myometrium during late pregnancy and labour.
Positive_regulation (induced) of Gene_expression (expression) of Hsp27 in myometrium associated with shock
4) Confidence 0.50 Published 2005 Journal Reproduction Section Title Doc Link 15615903 Disease Relevance 0.38 Pain Relevance 0.10
Hsp27 mRNA expression was significantly elevated (P <0.05) on days 17 to 22 of gestation.
Positive_regulation (elevated) of Gene_expression (expression) of Hsp27
5) Confidence 0.50 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.34 Pain Relevance 0.08
The active mechanism of bicyclol might be anti-apoptosis of hepatocytes through multiple signaling pathways mainly inducing the expressions of hepatic heat shock proteins (HSP27 and HSP70), molecular chaperons.
Positive_regulation (inducing) of Gene_expression (expressions) of HSP27 in hepatocytes associated with shock and apoptosis
6) Confidence 0.17 Published 2009 Journal Medicinal chemistry (Sh?riqah (United Arab Emirates)) Section Abstract Doc Link 19149648 Disease Relevance 1.28 Pain Relevance 0.14
In the literature, increased expression of HSP (HSP27, HSP70) plays an important role in reduced sensitivity towards cytostatic drugs [25–27].
Positive_regulation (increased) of Gene_expression (expression) of HSP27
7) Confidence 0.13 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.59 Pain Relevance 0

General Comments

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