INT12397

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 53
Total Number 55
Disease Relevance 9.10
Pain Relevance 31.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 7
oocytes 6
T cells 3
cerebellum 2
spinal cord 2
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 267 100.00 Very High Very High Very High
agonist 199 100.00 Very High Very High Very High
Opioid 96 100.00 Very High Very High Very High
Enkephalin 70 100.00 Very High Very High Very High
Delta opioid receptors 42 100.00 Very High Very High Very High
Analgesic 31 100.00 Very High Very High Very High
antinociception 26 100.00 Very High Very High Very High
Cholecystokinin 17 100.00 Very High Very High Very High
Neuropeptide 12 99.98 Very High Very High Very High
mu opioid receptor 40 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 67 99.82 Very High Very High Very High
Hypoxia 72 99.78 Very High Very High Very High
Glioma 2 99.36 Very High Very High Very High
Neuroblastoma 8 99.18 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 122 99.12 Very High Very High Very High
Neuropathic Pain 20 98.56 Very High Very High Very High
Injury 15 96.84 Very High Very High Very High
Cystic Fibrosis 2 96.12 Very High Very High Very High
Pain 33 96.08 Very High Very High Very High
Urological Neuroanatomy 4 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The delta-opioid receptor-1 (DOR-1) as well as delta-opioid enkephalin peptides are expressed during maturation of T cells, although the functional significance of their expression remains unclear.
Gene_expression (expressed) of delta-opioid receptor-1 in T cells associated with enkephalin, opioid receptor and opioid
1) Confidence 0.78 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15265667 Disease Relevance 0 Pain Relevance 0.51
The delta-opioid receptor-1 (DOR-1) as well as delta-opioid enkephalin peptides are expressed during maturation of T cells, although the functional significance of their expression remains unclear.
Gene_expression (expressed) of DOR-1 in T cells associated with enkephalin, opioid receptor and opioid
2) Confidence 0.78 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15265667 Disease Relevance 0 Pain Relevance 0.51
Prolonged exposure to hypoxia (9% oxygen, balance nitrogen) continuously for seven days selectively decreased delta opioid receptor expression in mouse brain homogenate.
Gene_expression (expression) of delta opioid receptor in brain associated with hypoxia and opioid receptor
3) Confidence 0.77 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.70 Pain Relevance 0.40
We tested the hypothesis that mice exposed to prolonged hypoxia have increased expression of the delta opioid receptor in brain tissue.
Gene_expression (expression) of delta opioid receptor in brain associated with hypoxia and opioid receptor
4) Confidence 0.77 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.70 Pain Relevance 0.36
Comparison of adjacent serial sections demonstrates that the delta-opioid receptor gene is indeed expressed exclusively in cholinergic interneurons in the striatum.
Gene_expression (expressed) of delta-opioid receptor gene in striatum associated with opioid receptor
5) Confidence 0.77 Published 1994 Journal Neuroscience Section Abstract Doc Link 7870294 Disease Relevance 0 Pain Relevance 0.67
In this context, we have used in situ hybridization histochemistry to determine the distribution of the delta-opioid receptor messenger RNA in the forebrain, and especially the phenotype of the neurons expressing the delta-opioid receptor gene in the striatum.
Gene_expression (expressing) of delta-opioid receptor gene in neurons associated with opioid receptor
6) Confidence 0.77 Published 1994 Journal Neuroscience Section Abstract Doc Link 7870294 Disease Relevance 0 Pain Relevance 0.64
Delta-opioid receptor gene expression in the mouse forebrain: localization in cholinergic neurons of the striatum.
Gene_expression (expression) of Delta-opioid receptor gene in forebrain associated with opioid receptor
7) Confidence 0.77 Published 1994 Journal Neuroscience Section Title Doc Link 7870294 Disease Relevance 0 Pain Relevance 0.57
Agonist regulation of the expression of the delta opioid receptor in NG108-15 cells.
Gene_expression (expression) of delta opioid receptor in NG108-15 associated with agonist and opioid receptor
8) Confidence 0.75 Published 1995 Journal FEBS Lett. Section Title Doc Link 8521954 Disease Relevance 0 Pain Relevance 0.64
The purpose of the present study was to compare the binding parameters, ligand-selectivity profile and pharmacological properties of the cloned mouse delta receptor (MDOR) stably expressed in a cell line to the delta(ncx) binding sites of mouse brain. [3H][D-Ala2,D-Leu5]enkephalin labeled a single binding site in membranes prepared from MDOR cells under several different assay conditions including BIT-pretreatment.
Gene_expression (expressed) of MDOR in brain associated with enkephalin
9) Confidence 0.74 Published 1998 Journal Peptides Section Abstract Doc Link 9493867 Disease Relevance 0 Pain Relevance 0.48
Cloned mouse delta-subtype opioid receptor (DOR1) was expressed in Xenopus oocytes to study the signal transduction.
Gene_expression (expressed) of DOR1 in oocytes associated with opioid receptor
10) Confidence 0.72 Published 1993 Journal FEBS Lett. Section Abstract Doc Link 8224200 Disease Relevance 0 Pain Relevance 0.50
Hypoxia decreases opioid delta receptor expression in mouse brain.
Gene_expression (expression) of opioid delta receptor in brain associated with hypoxia and opioid
11) Confidence 0.68 Published 1996 Journal Neuroscience Section Title Doc Link 9157323 Disease Relevance 0.70 Pain Relevance 0.46
Deletion of the delta opioid receptor gene increases motor impulsivity
Gene_expression (Deletion) of delta opioid receptor associated with opioid receptor and attention deficit hyperactivity disorder
12) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.40 Pain Relevance 0.14
11.55, p<.01] were the result of both Oprd1?
Gene_expression (result) of Oprd1
13) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.41 Pain Relevance 0.13
An antisense oligodeoxynucleotide (A-oligo) to delta-opioid receptor mRNA was utilized to block the expression of mouse delta-opioid receptor in the spinal cord of male ICR mice.
Gene_expression (expression) of delta-opioid receptor in spinal cord associated with opioid receptor and spinal cord
14) Confidence 0.66 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7925585 Disease Relevance 0 Pain Relevance 0.89
Furthermore, these results suggest that the rewarding effects of delta 1 opioid receptor agonist may be produced through activation of the central dopaminergic system, especially dopamine D1 receptors, whereas the rewarding effects of delta 2 opioid receptor agonists may be produced by some other mechanism(s).
Gene_expression (produced) of delta 2 opioid receptor associated with dopamine, agonist and opioid receptor
15) Confidence 0.63 Published 1996 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8740041 Disease Relevance 0 Pain Relevance 0.80
Cloned mouse delta-subtype opioid receptor (DOR1) was expressed in Xenopus oocytes to study the signal transduction.
Gene_expression (expressed) of delta-subtype opioid receptor in oocytes associated with opioid receptor
16) Confidence 0.63 Published 1993 Journal FEBS Lett. Section Abstract Doc Link 8224200 Disease Relevance 0 Pain Relevance 0.50
In membranes from Rat-1 fibroblasts transfected to express the murine delta-opioid receptor stably (clone D2 cells), the delta-opioid agonist [D-Ser2-Leu5-Thr6]enkephalin (DSLET) stimulated high affinity GTPase activity, which was inhibited by peptides that are derived from the proximal (i3.1) and the distal portions (i3.3) of the third intracellular loop with IC50 values of 15 +/- 5 and 50 +/- 4 microM, respectively.
Gene_expression (express) of delta-opioid receptor in proximal associated with mu agonist, enkephalin and opioid receptor
17) Confidence 0.61 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863845 Disease Relevance 0 Pain Relevance 0.43
No consistent changes in delta opioid receptor expression were detected in these brain regions.
Gene_expression (expression) of delta opioid receptor in brain associated with opioid receptor
18) Confidence 0.60 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.89 Pain Relevance 0.59
Shorter term hypoxic treatments (one day and three days) did not induce changes in delta opioid receptor expression in whole brain homogenate.
Gene_expression (expression) of delta opioid receptor in brain associated with hypoxia and opioid receptor
19) Confidence 0.60 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.76 Pain Relevance 0.51
Utilization of a microdissection technique followed by quantitative solution hybridization of RNA extracts from mouse brain revealed mean levels of DOR mRNA ranging from 3.9 pg/micrograms RNA in the caudate-putamen to 0.4 pg/micrograms RNA in the cerebellum.
Gene_expression (levels) of DOR mRNA in cerebellum associated with opioid receptor
20) Confidence 0.60 Published 1994 Journal J. Neurosci. Res. Section Abstract Doc Link 7897702 Disease Relevance 0 Pain Relevance 0.51

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