INT123970

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.29
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (BAG3) cytosol (BAG3) plasma membrane (BAG3)
cytoplasm (BAG3)
Anatomy Link Frequency
blood 1
BAG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 122 99.26 Very High Very High Very High
cva 281 99.20 Very High Very High Very High
Central nervous system 2 91.56 High High
Electroencephalography 22 85.96 High High
analgesia 15 50.00 Quite Low
imagery 5 28.80 Quite Low
Pain 102 10.24 Low Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
Catecholamine 9 5.00 Very Low Very Low Very Low
Analgesic 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 271 99.20 Very High Very High Very High
Sleep Disorders 216 98.92 Very High Very High Very High
Death 10 98.68 Very High Very High Very High
Injury 35 98.40 Very High Very High Very High
Cv Unclassified Under Development 5 96.32 Very High Very High Very High
Cerebral Hypoxia 12 93.96 High High
Brain Injury 52 91.28 High High
Hypertension 2 90.08 High High
Hematoma 4 85.68 High High
Critical Illness 35 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As well, increased ICP or decreased CPP are associated with a reduction in BIS.
Negative_regulation (reduction) of BIS associated with cva
1) Confidence 0.38 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.58 Pain Relevance 0.55
The decrease in BIS was suspected to be the result of decreased cerebral blood flow.
Negative_regulation (decrease) of BIS in blood
2) Confidence 0.38 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15616071 Disease Relevance 0.40 Pain Relevance 0.46
BIS decreased to near 0 on 2 occasions: after anesthesia induction and shortly after the start of the surgery.
Negative_regulation (decreased) of BIS associated with anesthesia
3) Confidence 0.38 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15616071 Disease Relevance 0.43 Pain Relevance 0.50
Initially lower and further decreasing BIS values were associated with the death of the patient at the second CPR (Fig. 2).
Negative_regulation (decreasing) of BIS associated with death
4) Confidence 0.29 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.37 Pain Relevance 0
Additional investigations may prove that a marginal ICP in blunt trauma patients with intracranial hemorrhage and GCS score 3 to 8 does not need to be lowered with BIS ?
Negative_regulation (lowered) of BIS associated with injury and cva
5) Confidence 0.27 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.68 Pain Relevance 0.51
There are no units of measurement and one patient's response to a sedation agent may be dependent on many factors, so whether a BIS number can correlate uniformly with depth of sedation remains controversial.
Negative_regulation (number) of BIS associated with sleep disorders
6) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2391268 Disease Relevance 0.34 Pain Relevance 0.17
During the second hour the MOAAS score dropped to a median of 3 with a corresponding decrease in the BIS to a mean value of 61 ± 11.
Negative_regulation (decrease) of BIS
7) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2801588 Disease Relevance 0.14 Pain Relevance 0
For the fospropofol group the reduction in BIS was of a comparable amount, although the slope of the drop was steeper and the duration was prolonged versus the propofol group.
Negative_regulation (reduction) of BIS
8) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2801588 Disease Relevance 0.07 Pain Relevance 0
Likewise with deepening of sleep -which could be monitored also with BIS- the N1 component diminished.
Negative_regulation (diminished) of BIS
9) Confidence 0.05 Published 2010 Journal Nonlinear Biomed Phys Section Body Doc Link PMC2880803 Disease Relevance 0 Pain Relevance 0.22
Accordingly, the increments of propofol resulted in decreasing of the BIS index (p<0.0001) (Table 2).
Negative_regulation (decreasing) of BIS
10) Confidence 0.05 Published 2010 Journal Nonlinear Biomed Phys Section Body Doc Link PMC2880803 Disease Relevance 0 Pain Relevance 0
A correlation between BIS values and the administrated dose of intravenous and inhalational anesthetics has been demonstrated: the progressive deepening of anesthesia induces a corresponding progressive reduction in BIS values [5].
Negative_regulation (reduction) of BIS associated with anesthesia
11) Confidence 0.03 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC2889282 Disease Relevance 0.28 Pain Relevance 0.21
The Emax is the maximal effect also fixed to 100 and EC50 is the concentration for 50% decrease in BIS score.
Negative_regulation (decrease) of BIS
12) Confidence 0.03 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC2889282 Disease Relevance 0 Pain Relevance 0

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