INT123978

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.50
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 60 100.00 Very High Very High Very High
antagonist 8 100.00 Very High Very High Very High
nMDA receptor antagonist 1 100.00 Very High Very High Very High
depression 25 98.20 Very High Very High Very High
Migraine 187 97.56 Very High Very High Very High
tolerance 1 95.68 Very High Very High Very High
Lasting pain 1 94.92 High High
Glutamate receptor 29 86.44 High High
nMDA receptor 1 74.92 Quite High
central sensitization 4 74.52 Quite High
Disease Link Frequency Relevance Heat
Depression 25 98.20 Very High Very High Very High
Headache 183 97.56 Very High Very High Very High
Epilepsy 21 95.28 Very High Very High Very High
Pain 1 94.92 High High
Hemiplegia 1 94.36 High High
Deafness 1 93.88 High High
Shock 8 92.72 High High
Liver Disease 1 91.96 High High
Schizophrenia 1 91.36 High High
Anxiety Disorder 1 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional analysis of the associated GRIA1 variants
GRIA1 Binding (associated) of
1) Confidence 0.41 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.09 Pain Relevance 0
Whereas the rs548294 variant in GRIA1 gene showed association primarily with MO phenotype, supporting the hypothesis that MA and MO phenotypes could be genetically related.
GRIA1 gene Binding (association) of
2) Confidence 0.37 Published 2010 Journal BMC Med. Genet. Section Body Doc Link 20579352 Disease Relevance 0.08 Pain Relevance 0
Interestingly, both the GRIA1 and GRIA3 variants were specifically associated with MA suggesting a role of these genes in CSD, which is retained to be the path physiological mechanism-underlying aura.
GRIA1 Binding (associated) of associated with epilepsy and depression
3) Confidence 0.37 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.91 Pain Relevance 0.90
In fact, the rs548294 SNP in GRIA1 gene was primarily associated with MO rather than MA.
GRIA1 Binding (associated) of
4) Confidence 0.37 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.71 Pain Relevance 0.66
More complex is the case of GRIA1 gene where only the -2012C>T variant seems to affect the binding affinity of the GRIA1 promoter with transcription factor(s) and the variant T allele has a stronger binding strength compared with the C allele.
GRIA1 Binding (affinity) of
5) Confidence 0.35 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.38 Pain Relevance 0.36
Finally, the authors cite the progress achieved in the development of agents that interact with the glutamatergic system: NMDA channel blockers, competitive NMDA receptor antagonists, NR2B-selective antagonists, glutamate release inhibitors, glycineB antagonists, AMPA and kainate receptor antagonists, AMPA receptor-positive modulators and agents that act by modifying endogenous kynurenic acid metabolism.
AMPA Binding (interact) of associated with glutamate, nmda receptor antagonist and antagonist
6) Confidence 0.09 Published 1998 Journal Drug News Perspect. Section Abstract Doc Link 15616669 Disease Relevance 1.34 Pain Relevance 0.70

General Comments

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