INT123990

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.85
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
spinal cord 1
nucleus 1
Ctnnb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 98.76 Very High Very High Very High
withdrawal 7 98.48 Very High Very High Very High
Abeta 3 97.84 Very High Very High Very High
Spinal cord 4 97.76 Very High Very High Very High
cocaine 105 96.40 Very High Very High Very High
Inflammation 23 95.92 Very High Very High Very High
depression 1 88.88 High High
cINOD 4 87.68 High High
antidepressant 2 86.12 High High
Nucleus accumbens 35 85.60 High High
Disease Link Frequency Relevance Heat
Obesity 8 99.92 Very High Very High Very High
Opiate Addiction 2 98.76 Very High Very High Very High
Toxicity 1 97.60 Very High Very High Very High
INFLAMMATION 29 95.92 Very High Very High Very High
Nociception 2 95.04 Very High Very High Very High
Colon Cancer 2 93.92 High High
Drug Induced Neurotoxicity 2 92.52 High High
Depression 1 88.88 High High
Coronary Artery Disease 4 85.92 High High
Aids-related Complex 11 84.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, they demonstrated that beta-catenin, a transcription factor downstream of Akt, was induced during morphine withdrawal, particularly during recurrent withdrawal.
Positive_regulation (induced) of beta-catenin
1) Confidence 0.43 Published 2006 Journal Anesthesiology Section Body Doc Link 16810007 Disease Relevance 0 Pain Relevance 0
However, in the azoxymethane-treated rat, where beta-catenin is frequently rendered GSK-3beta-insensitive, nabumetone failed to alter beta-catenin levels but did decrease beta-catenin nuclear localization and transcriptional activity as gauged by cyclin D1.
Positive_regulation (rendered) of beta-catenin
2) Confidence 0.39 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.25 Pain Relevance 0.12
We report that nabumetone decreased uninvolved intestinal mucosal beta-catenin levels in the MIN mouse with a concomitant increase in glycogen synthase kinase (GSK)-3beta levels, an enzyme that targets beta-catenin for destruction.
Positive_regulation (increase) of beta-catenin
3) Confidence 0.36 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15617833 Disease Relevance 0.26 Pain Relevance 0.12
Increased prostaglandin E2 release and activated Akt/beta-catenin signaling pathway occur after opioid withdrawal in rat spinal cord.
Positive_regulation (activated) of beta-catenin in spinal cord associated with withdrawal, opioid and spinal cord
4) Confidence 0.19 Published 2006 Journal Anesthesiology Section Title Doc Link 16810007 Disease Relevance 0.19 Pain Relevance 0.38
Beta-catenin, which was increased at 10-days of abstinence in this study, is a well-characterized protein that regulates cell growth as a part of the Wnt signaling pathway.
Positive_regulation (increased) of Beta-catenin
5) Confidence 0.09 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.22 Pain Relevance 0.37
and an up-regulation of beta-catenin.
Positive_regulation (up-regulation) of beta-catenin
6) Confidence 0.05 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.34 Pain Relevance 0.18
IBU-PO (0.01-1 microM) inhibits glycogen-synthase-kinase-3beta (GSK-3beta) and stabilizes cytoplasmic beta-catenin reverting the silencing of the Wnt pathway caused by Abeta-toxicity and GSK-3beta overexpression.
Positive_regulation (stabilizes) of cytoplasmic beta-catenin associated with toxicity and abeta
7) Confidence 0.03 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.58 Pain Relevance 0.34
They also showed that T inhibited adipogenic differentiation of pre-adipocytes by activation of androgen receptor (AR)/beta-catenin interaction and translocation of androgen receptor/beta catenin complex to the nucleus, thus bypassing canonical Wnt signalling.
Positive_regulation (activation) of beta-catenin in nucleus associated with obesity
8) Confidence 0.03 Published 2008 Journal Cardiovasc Diabetol Section Body Doc Link PMC2576082 Disease Relevance 1.02 Pain Relevance 0.13

General Comments

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