INT124010

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.70
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tsc22d1) cytoplasm (Tsc22d1)
Tsc22d1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 2 84.12 Quite High
Disease Link Frequency Relevance Heat
Cancer 6 99.24 Very High Very High Very High
Liver Cancer 3 91.64 High High
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We selected two potential transcriptional targets of Tsc-22, growth arrest and DNA damage-inducible gene 45 beta (Gadd45b) and leucine zipper, putative tumor suppressor 2 (Lzts2) to test based on our previous complementary DNA microarray studies, showing that expression of these cancer-associated genes was increased when Tsc-22 was repressed.
Regulation (targets) of Tsc-22 associated with cancer
1) Confidence 0.27 Published 2007 Journal Toxicol. Sci. Section Abstract Doc Link 17533171 Disease Relevance 0.51 Pain Relevance 0.08
The analyses revealed that several cancer-related genes, including Fhit, Wwox, Tsc-22 and Gadd45b, were induced or repressed in unique patterns for specific carcinogens and not altered by the non-carcinogens.
Neg (not) Regulation (altered) of Tsc-22 associated with cancer
2) Confidence 0.26 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15618236 Disease Relevance 0.19 Pain Relevance 0.07

General Comments

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