INT124028

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Context Info
Confidence 0.80
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 2.04
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Anatomy Link Frequency
neurons 2
dorsal root ganglion 2
sensory neurons 1
cerebral cortex 1
larynx 1
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Root ganglion neuron 92 100.00 Very High Very High Very High
agonist 68 99.84 Very High Very High Very High
qutenza 109 99.80 Very High Very High Very High
Inflammation 10 99.36 Very High Very High Very High
vanilloid receptor subtype 1 5 98.52 Very High Very High Very High
cerebral cortex 4 97.96 Very High Very High Very High
Osm-9-like TRP channel 2 3 96.44 Very High Very High Very High
TRP channel 125 96.12 Very High Very High Very High
substance P 3 92.60 High High
Calcitonin gene-related peptide 3 91.76 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 112 100.00 Very High Very High Very High
INFLAMMATION 5 99.36 Very High Very High Very High
Nociception 4 96.64 Very High Very High Very High
Pruritus 12 75.20 Quite High
Neurogenic Inflammation 2 75.00 Quite High
Pain 20 74.24 Quite High
Dermatitis 1 61.36 Quite High
Loss Of Sense Of Smell 8 5.00 Very Low Very Low Very Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low
Bites And Stings 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We extended the search for TRPV1-TRPV2 co-localization in the brain, where we detected extensive co-expression of the two receptors in the IV, V and VI layer neurons of the adult rat cerebral cortex.
Localization (co-localization) of TRPV2 in neurons associated with cerebral cortex
1) Confidence 0.80 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16115206 Disease Relevance 0.07 Pain Relevance 0.32
Immunolocalization of VR1 and VRL1 in rat larynx.
Localization (Immunolocalization) of VRL1 in larynx
2) Confidence 0.79 Published 2005 Journal Auton Neurosci Section Title Doc Link 15620571 Disease Relevance 0 Pain Relevance 1.07
Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex.
Localization (co-localization) of TRPV2 in cerebral cortex associated with qutenza and cerebral cortex
3) Confidence 0.74 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16115206 Disease Relevance 0.09 Pain Relevance 0.44
The probenecid-sensitive neurons were mainly distributed in a medium to large-diameter population, in agreement with previous observations with TRPV2 immunolocalization.
Localization (immunolocalization) of TRPV2 in neurons
4) Confidence 0.68 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17850966 Disease Relevance 0.25 Pain Relevance 0.36
Citral initially increased the agonist-evoked responses of TRPV1, TRPV2, and TRPV3 (Fig. 2A, B).
Localization (responses) of TRPV2 associated with agonist
5) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.52
In contrast, previous immunohistochemical study of adult rats indicated that TRPV2 was in <20% of dorsal root ganglion neurons [28]–[30]) and TRPV1 colocalized with TRPV2 in <30% of the TRPV1-positive population [29], [42], [43].
Localization (colocalized) of TRPV2 in dorsal root ganglion associated with ganglion cysts and root ganglion neuron
6) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.45 Pain Relevance 0.31
The remaining TRPV2 or TRPV3 channels could then be separated.
Localization (separated) of TRPV2
7) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.13 Pain Relevance 0.23
In contrast, previous immunohistochemical study of adult rats indicated that TRPV2 was in <20% of dorsal root ganglion neurons [28]–[30]) and TRPV1 colocalized with TRPV2 in <30% of the TRPV1-positive population [29], [42], [43].
Localization (colocalized) of TRPV2 in dorsal root ganglion associated with ganglion cysts and root ganglion neuron
8) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.44 Pain Relevance 0.28
The temperature-sensitive transient receptor potential (TRP) channels, is also called thermo TRP, including TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1, which are expressed in sensory neurons and non-neuronal cells (e.g.keratinocyte, mast cell) of the skin.
Localization (called) of TRPV2 in sensory neurons
9) Confidence 0.21 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 19693981 Disease Relevance 0.60 Pain Relevance 0.42

General Comments

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