INT124042

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.13
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF7) extracellular space (FGF7) extracellular region (FGF7)
Golgi apparatus (FGF7)
Anatomy Link Frequency
keratinocytes 3
fibroblasts 2
HGF 1
FGF7 (Homo sapiens)
Pain Link Frequency Relevance Heat
IPN 4 97.32 Very High Very High Very High
metalloproteinase 2 76.44 Quite High
Pain 17 72.68 Quite High
Opioid 2 60.00 Quite High
Analgesic 3 59.44 Quite High
Inflammation 21 48.80 Quite Low
pruritus 1 38.56 Quite Low
Hypoesthesia 1 36.40 Quite Low
Paresthesia 1 35.28 Quite Low
cytokine 7 31.04 Quite Low
Disease Link Frequency Relevance Heat
Cancer 624 99.60 Very High Very High Very High
Injury 13 95.44 Very High Very High Very High
Colon Cancer 2 94.92 High High
Adhesions 3 94.80 High High
Salivary Gland Disease 7 87.68 High High
Apoptosis 10 86.52 High High
Solid Tumor 1 85.16 High High
Mucositis 63 78.80 Quite High
Prostate Cancer 53 73.32 Quite High
Pain 17 72.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, the secretion of a protein detectable by a KGF-specific ELISA into the culture medium of fibroblasts and epithelial tumour cells was confirmed.
Localization (secretion) of KGF in fibroblasts associated with cancer
1) Confidence 0.80 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.54 Pain Relevance 0
Measurements were performed in triplicate, and experiments were repeated at least three times. b KGF-induced (0.2 ?
Localization (repeated) of KGF
2) Confidence 0.75 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.12 Pain Relevance 0
Primary antibodies were for KGF MAB2511 Clone 29568, dilution 1:250; for KGF receptor MAB665 Clone 98707, dilution 1:250 (both R&D Systems) and for actin IgG1, dilution 1:1,000 (Santa Cruz, Santa Cruz, USA).
Localization (for) of KGF receptor
3) Confidence 0.75 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.19 Pain Relevance 0
The secretion of KGF protein into the culture medium was tested for fibroblasts (DF-19), tumour cell cultures (BW-225, GR-145, OH-65, ZMK-1), and immortalized keratinocytes (HaCat) by ELISA.
Localization (secretion) of KGF protein in keratinocytes associated with cancer
4) Confidence 0.71 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.42 Pain Relevance 0
For confirmation, immortalized keratinocytes (HaCat cells) were tested and showed KGF mRNA expression and secretion as well.
Localization (secretion) of KGF mRNA in keratinocytes
5) Confidence 0.71 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.36 Pain Relevance 0
In summary, the delivered exogenous huKGF (i.e., released from a biomaterial matrix) operates in tandem with fibroblasts in regulating keratinocyte activation (i.e., IL-lbeta release and adhesion) in a surface-dependent manner.
Localization (released) of KGF in fibroblasts associated with adhesions
6) Confidence 0.68 Published 2005 Journal Biomaterials Section Abstract Doc Link 15621258 Disease Relevance 0.09 Pain Relevance 0.34
Consistent with this hypothesis, paracrine growth factors that are normally secreted by prostate stroma cells, such as epidermal growth factor (EGF), insulin-like growth factor 1 (IGF1), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) or interleukin 6 (IL6), are found to be overexpression in hormone-refractory cancer in association with a switch to autocrine production by cancer epithelial cells [16].
Localization (secreted) of KGF in HGF associated with cancer
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.65 Pain Relevance 0
A truncated recombinant form of human KGF (?
Localization (form) of KGF
8) Confidence 0.65 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.26 Pain Relevance 0.07
In a phase I trial, Meropol determined that KGF was well tolerated at doses up to 40 ?
Localization (tolerated) of KGF
9) Confidence 0.62 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 1.09 Pain Relevance 0.16
Tumour cells are known to secrete growth factors other than KGF; however, two findings support the assumption that tumour-cell-derived KGF was causative for the observed stimulated proliferation of keratinocytes.
Localization (secrete) of KGF in keratinocytes associated with cancer
10) Confidence 0.62 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.41 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox