INT124052

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.52
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkce) Golgi apparatus (Prkce) endoplasmic reticulum (Prkce)
enzyme binding (Prkce) cytoplasm (Prkce) cytosol (Prkce)
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 27 99.64 Very High Very High Very High
Lasting pain 2 95.80 Very High Very High Very High
Inflammation 15 91.20 High High
Inflammatory stimuli 1 91.08 High High
Kinase C 1 77.84 Quite High
agonist 2 38.16 Quite Low
IPN 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 29 99.64 Very High Very High Very High
Pain 2 95.80 Very High Very High Very High
INFLAMMATION 10 91.20 High High
Inflammatory Pain 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK).
PKCepsilon Binding (combination) of associated with hyperalgesia
1) Confidence 0.06 Published 2005 Journal Pain Section Abstract Doc Link 15836982 Disease Relevance 0.92 Pain Relevance 0.79
PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK).
kinase Cepsilon Binding (combination) of associated with hyperalgesia
2) Confidence 0.05 Published 2005 Journal Pain Section Abstract Doc Link 15836982 Disease Relevance 0.91 Pain Relevance 0.79
Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways.
PKCepsilon Binding (interaction) of associated with hyperalgesia
3) Confidence 0.03 Published 2005 Journal Pain Section Title Doc Link 15621379 Disease Relevance 0.69 Pain Relevance 0.45

General Comments

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