INT124063

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.22
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFR) small molecule metabolic process (MTHFR) oxidoreductase activity (MTHFR)
cellular amino acid metabolic process (MTHFR)
MTHFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 99.80 Very High Very High Very High
methotrexate 39 99.06 Very High Very High Very High
Migraine 65 98.44 Very High Very High Very High
Catechol-O-methyltransferase 218 96.84 Very High Very High Very High
Inflammation 97 91.32 High High
imagery 1 89.64 High High
adenocard 3 85.84 High High
headache 20 81.60 Quite High
rheumatoid arthritis 63 71.40 Quite High
chemokine 4 61.40 Quite High
Disease Link Frequency Relevance Heat
Headache 84 98.44 Very High Very High Very High
Hantavirus Infection 156 95.00 High High
Colon Cancer 396 94.40 High High
Migraine With Aura 21 94.40 High High
INFLAMMATION 100 91.32 High High
Cancer 69 91.16 High High
Cardiovascular Disease 9 90.28 High High
Neurodegenerative Disease 4 89.32 High High
Diplopia 1 87.04 High High
Paresis 1 85.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, factor V Leiden mutation, prothrombin mutation G20210A and MTHFR mutation were searched for.
Gene_expression (searched) of MTHFR
1) Confidence 0.65 Published 2004 Journal Neurol. Sci. Section Abstract Doc Link 15624088 Disease Relevance 0.88 Pain Relevance 0.13
The fifth gene highlighted by our analyses, MTHFR (5,10-methylenetetrahydrofolate reductase), is part of the one-carbon metabolic pathway, involved in both DNA methylation and DNA synthesis.
Gene_expression (reductase) of 5,10-methylenetetrahydrofolate
2) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.59 Pain Relevance 0.11
The most predisposing patterns for this combination, presented in Table 2, combine genotypes 1 and 2 for PTGS1 c.639C>A, IL8 c.-352T>A, and MTHFR c.1286A>C, and 0 for PLA2G2A c.435+230C>T and PPARG c.1431C>T.
Gene_expression (c.1286A>C) of MTHFR
3) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.36 Pain Relevance 0
The MTHFR enzyme synthesizes 5-methyltetrahydrofolate, the primary circulatory form of folate, which represents a fundamental methyl donor in cellular metabolism [26].
Gene_expression (synthesizes) of MTHFR
4) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.59 Pain Relevance 0.10
The fifth gene highlighted by our analyses, MTHFR (5,10-methylenetetrahydrofolate reductase), is part of the one-carbon metabolic pathway, involved in both DNA methylation and DNA synthesis.
Gene_expression (reductase) of MTHFR
5) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.59 Pain Relevance 0.11
Functional polymorphisms in genes relevant to homocysteine metabolism (e.g., 5,10-methylenetetrahydrofolate reductase; MTHFR and glutamate carboxypepidase II; GCPII [59]–[61]) that result in accumulation of SAH likely augment the effects of APS and HPS haplotypes.
Gene_expression (reductase) of MTHFR associated with glutamate and hantavirus infection
6) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.84 Pain Relevance 0.24
Gender differences and the MTHFR genotype
Gene_expression (genotype) of MTHFR
7) Confidence 0.56 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 1.12 Pain Relevance 0.84
Functional polymorphisms in genes relevant to homocysteine metabolism (e.g., 5,10-methylenetetrahydrofolate reductase; MTHFR and glutamate carboxypepidase II; GCPII [59]–[61]) that result in accumulation of SAH likely augment the effects of APS and HPS haplotypes.
Gene_expression (reductase) of 5,10-methylenetetrahydrofolate associated with glutamate and hantavirus infection
8) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.85 Pain Relevance 0.24
Other folate enzymes are not directly inhibited by MTX, such as methylenetetrahydrofolate reductase (MTHFR), but their expression level may contribute to the antifolate effects of MTX [57].
Gene_expression (expression) of MTHFR associated with methotrexate
9) Confidence 0.37 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.39 Pain Relevance 0.90

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