INT124069

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.32
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
ligament 1
nerve 1
neurons 1
knee 1
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 99 99.48 Very High Very High Very High
Pain 78 98.12 Very High Very High Very High
dorsal root ganglion 57 89.52 High High
nociceptor 23 87.20 High High
Nerve growth factor 30 83.00 Quite High
depression 74 50.00 Quite Low
Spinal cord 14 42.48 Quite Low
IPN 1 41.76 Quite Low
Central nervous system 8 40.08 Quite Low
Cancer pain 23 38.88 Quite Low
Disease Link Frequency Relevance Heat
Cancer 58 99.52 Very High Very High Very High
Frailty 77 99.48 Very High Very High Very High
Pain 76 98.12 Very High Very High Very High
Neuroma 25 97.64 Very High Very High Very High
Disease Progression 4 95.32 Very High Very High Very High
Obesity 24 94.60 High High
Apoptosis 8 93.20 High High
Ganglion Cysts 60 89.52 High High
Targeted Disruption 24 86.68 High High
Osteophyte 7 84.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They observed that Runx3 co-localizes not only with TrkC, but also TrkA and TrkB at postnatal day 0 (P0) [30].
Localization (localizes) of TrkA
1) Confidence 0.59 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 1.01 Pain Relevance 0.31
Epitope mapping studies, by serial deletion mutants and by phage display, reveal a conformational epitope that is localized on the carboxy-terminal region of the first immunoglobulin-like domain (d4) of TrkA.
Localization (localized) of TrkA
2) Confidence 0.56 Published 2005 Journal Proteins Section Abstract Doc Link 15625712 Disease Relevance 0 Pain Relevance 0
Early blockade of Trk's attenuates tumor-induced nerve sprouting and formation of neuroma-like structures and does not significantly affect disease progression
Localization (blockade) of Trk's in nerve associated with cancer, neuroma and disease progression
3) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.84 Pain Relevance 0
In the adult, Grik1/GluR5 never co-localized with TrkA and was restricted to small cell-diameter c-Ret+/isolectin B4+ neurons.
Localization (localized) of TrkA in neurons
4) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.22
Bicruciate ligament retention in TKR has been evaluated since the earliest non hinged implants since the late 1960s.
Localization (retention) of TKR in ligament
5) Confidence 0.37 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656980 Disease Relevance 0 Pain Relevance 0
Male farmers differed significantly from other work classes, having a greatly increased likelihood for both TKR and THR for OA.
Localization (likelihood) of TKR associated with osteoarthritis
6) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911890 Disease Relevance 0.19 Pain Relevance 0.10
Binding of a neurotrophin to the appropriate Trk receptor leads to the dimerization and transphosphorylation of tyrosine residues in the intracellular domain of the Trk receptors and subsequent activation of cytoplasmic signaling pathways.50,51 All neurotrophins can bind to the pan75 neurotrophin receptor (p75NTR), which plays a role in neurotrophin transport, ligand binding specificity, and Trk functioning.44,52,53
Localization (receptor) of Trk
7) Confidence 0.10 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.11
Baseline floor effects, indicating worst possible scores, were present in the RP subscale for all groups and the RE subscale for THR, TKR, and ACL groups (see Table 4).
Localization (subscale) of TKR
8) Confidence 0.07 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2527304 Disease Relevance 0.55 Pain Relevance 0.27
The items included age on the day of hospitalization before TKR, sex, height and weight, and duration of knee pain.
Localization (hospitalization) of TKR in knee associated with pain
9) Confidence 0.04 Published 2008 Journal Skeletal Radiol Section Body Doc Link PMC2525847 Disease Relevance 0.60 Pain Relevance 0.13

General Comments

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