INT124076

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 1.01
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
brain 1
lungs 1
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 98.44 Very High Very High Very High
Inflammation 7 93.84 High High
ischemia 31 73.12 Quite High
dexamethasone 1 66.92 Quite High
Intracerebroventricular 6 58.40 Quite High
anesthesia 7 44.72 Quite Low
ketamine 6 41.60 Quite Low
cva 7 40.24 Quite Low
Central nervous system 24 17.08 Low Low
imagery 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 98.24 Very High Very High Very High
Osteoarthritis 12 81.36 Quite High
Apoptosis 6 78.80 Quite High
Radiation Pneumonitis 2 75.00 Quite High
Brain Hemorrhage 12 73.60 Quite High
Pressure And Volume Under Development 2 68.00 Quite High
Adult Respiratory Distress Syndrome 14 66.64 Quite High
Stroke 6 57.80 Quite High
Targeted Disruption 6 54.32 Quite High
Hypoxia 20 45.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Occludin 1 did not decrease in the lungs of rats treated with the anti-inflammatory drugs as it did in most rats treated only with saline.
Occludin 1 Neg (not) Binding (decrease) of in lungs associated with inflammation and cinod
1) Confidence 0.37 Published 2004 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 15625787 Disease Relevance 0.32 Pain Relevance 0.21
Given that the phosphorylation of the proteins is an immediate event and the disruption of the BBB also occurs shortly after sonication, it is plausible that the ultrasound-mediated diminished interaction of occludin and ZO-1 is due to alteration in phosphorylation level of tight junction proteins.
occludin Binding (interaction) of
2) Confidence 0.22 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.07 Pain Relevance 0.04
The extracellular domains of occludin form homotypic interactions with adjacent cells.
occludin Binding (interactions) of
3) Confidence 0.22 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
However, using immunoprecipitation analysis we show that the interaction of occludin and ZO-1 is reduced in the brain regions treated with ultrasound (Figure 3B).


occludin Binding (interaction) of in brain
4) Confidence 0.22 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
In the following study we show that the application of focused ultrasound in combination with ultrasound contrast agent disrupts the BBB integrity, and that this disruption is associated with reduced interaction of the tight junction protein occludin with ZO-1.
occludin Binding (interaction) of
5) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.14 Pain Relevance 0
Our data provides evidence that focused ultrasound in the presence of circulating ultrasound contrast agents (microbubbles) disrupts the interaction of tight junction proteins (occludin and ZO-1), thus affecting the integrity of the BBB.
occludin Binding (interaction) of
6) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.27 Pain Relevance 0.06
It has been shown that the post-translational modifications play an essential role in controlling the interaction of occludin and ZO-1.
occludin Binding (interaction) of
7) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.07 Pain Relevance 0.04
Treatment with U0126 resulted in smoother junctional staining of occluding and claudin 4 in 2CLP monolayers, although some occludin junctional blebbing was observed.
occludin Binding (blebbing) of
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.13 Pain Relevance 0

General Comments

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