INT124077

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.62
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
lungs 1
large intestine 1
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 81 99.38 Very High Very High Very High
cINOD 6 98.44 Very High Very High Very High
ischemia 33 96.52 Very High Very High Very High
Inflammation 18 93.84 High High
IPN 5 90.32 High High
Bile 64 90.24 High High
anesthesia 17 84.96 Quite High
Hyperalgesia 2 78.60 Quite High
withdrawal 2 75.52 Quite High
halothane 1 69.96 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 640 99.52 Very High Very High Very High
Adhesions 4 99.36 Very High Very High Very High
INFLAMMATION 26 98.24 Very High Very High Very High
Cv Unclassified Under Development 18 96.52 Very High Very High Very High
Brain Hemorrhage 62 94.80 High High
Pressure And Volume Under Development 31 92.24 High High
Targeted Disruption 12 92.16 High High
Increased Venous Pressure Under Development 9 88.24 High High
Diabetic Macular Edema 55 86.80 High High
Injury 49 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the transmembrane TJ proteins occludin and claudin-3 and -5 significantly changed with CFA treatment with a 60% decrease in occludin, a 450% increase in claudin-3, and a 615% increase in claudin-5 expression.
Negative_regulation (decrease) of occludin
1) Confidence 0.57 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15792985 Disease Relevance 0.62 Pain Relevance 0.76
Occludin 1 did not decrease in the lungs of rats treated with the anti-inflammatory drugs as it did in most rats treated only with saline.
Neg (not) Negative_regulation (decrease) of Occludin 1 in lungs associated with inflammation and cinod
2) Confidence 0.43 Published 2004 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 15625787 Disease Relevance 0.32 Pain Relevance 0.21
Chehade et al. (37) reported that occludin but not zona occludens-1 levels are decreased at 2 weeks after the induction of diabetes by STZ injection.
Negative_regulation (decreased) of occludin associated with diabetes mellitus
3) Confidence 0.36 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.80 Pain Relevance 0.18
In the current study, MMP-9 was increased in microvessel preparation along with decreased occludin.
Negative_regulation (decreased) of occludin associated with metalloproteinase
4) Confidence 0.32 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.99 Pain Relevance 0.19
Cerebrovascular permeability, matrix metalloproteinase (MMP)-9 protein level, and total MMP activity were augmented while occludin was decreased in isolated cerebrovessels of the GK group.
Negative_regulation (decreased) of occludin associated with metalloproteinase
5) Confidence 0.23 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797926 Disease Relevance 1.09 Pain Relevance 0.18
Furthermore, immunoelectron microscopy showed that this effect is associated with delocalization as well as diminished immunogold signals of tight junctional proteins, including occludin, claudin 5 and ZO-1 [15].
Negative_regulation (diminished) of occludin
6) Confidence 0.20 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Claudin 4, claudin 18, and occludin were all significantly reduced in 2CLP monolayers compared to sham, while no significant differences in the expression of claudin 3, 5, 7, 8, ZO-1, and JAM-A were observed.
Negative_regulation (reduced) of occludin
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.15 Pain Relevance 0
The barrier protein occludin is decreased in experimental diabetes [21].
Negative_regulation (decreased) of occludin associated with diabetes mellitus
8) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.77 Pain Relevance 0
rAAV-angiostatin influence on occludin loss
Negative_regulation (loss) of occludin
9) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.56 Pain Relevance 0
Furthermore, VEGF affects the tight junction protein occludin, inducing occludin phosphorylation [19] and redistribution [20]; resultant occludin reduction is associated with BRB breakdown in diabetes [21].
Negative_regulation (reduction) of occludin associated with diabetes mellitus
10) Confidence 0.10 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.81 Pain Relevance 0
This effect is associated with downregulation of retinal VEGF and phospho-p42/p44 MAP kinase expression, and a reduction in the retinal occludin loss induced by diabetes.
Negative_regulation (reduction) of occludin associated with diabetes mellitus
11) Confidence 0.10 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.89 Pain Relevance 0.03
This effect is associated with downregulation of retinal VEGF and phospho-p42/p44 MAP kinase expression, and a reduction in the retinal occludin loss induced by diabetes.
Negative_regulation (loss) of occludin associated with diabetes mellitus
12) Confidence 0.10 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.89 Pain Relevance 0.03
Feeding the high fat diet increased intestinal permeability in both the OLETF and LETO rats, and the increases correlated with decreases in TJ proteins (claudin-1, claudin-3, occludin and junctional adhesion molecule-1) expression in the small, but not in the large intestine (cecum or colon).
Negative_regulation (decreases) of occludin in large intestine associated with adhesions
13) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2848226 Disease Relevance 0.72 Pain Relevance 0.23

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