INT124092

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Myo1b) cytoplasm (Myo1b)
Anatomy Link Frequency
macrophage 1
spines 1
Myo1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 25 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
Dextromethorphan 14 99.38 Very High Very High Very High
dopaminergic neurodegeneration 1 61.76 Quite High
Opioid 1 57.28 Quite High
antagonist 1 53.44 Quite High
cytokine 11 10.96 Low Low
interstitial cystitis 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 29 100.00 Very High Very High Very High
Adhesions 5 100.00 Very High Very High Very High
Death 7 93.76 High High
Necrosis 2 90.92 High High
Liver Cancer 1 90.56 High High
Cancer 29 89.92 High High
Hepatotoxicity 2 82.16 Quite High
Bacterial Infection 1 75.00 Quite High
Shock 1 66.36 Quite High
Cough 1 57.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is worth noting in the context of analogies between the podocyte slit diaphragm and neuronal dendrites that numerous mRNAs that encode dendritic proteins are themselves localized to dendritic spines where they appear to be dynamically translated at their sites of expression [60] Just as a number of the proteins encoded by these mRNA are localized to dendrites, it is also noteworthy that 15 of the enriched mRNAs themselves have been shown to localize to dendritic spines, the post-synaptic density, or (in one case) at the post-synaptic membrane of the neuromuscular junction: Ppp1r9b, Dbn1, Myh9, Plec1, Spna2, Spnb2, Actn4, Actn1, Gsn, Nes, Pls3, Utrn, Dst, Myo1b, Shrm [61]–[69].
Gene_expression (expression) of Myo1b in spines
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
-estradiol metabolism, including: WISP2, ROCK1 (Rho-GTP binding), MYO1B, S100A13, and CD55.
Gene_expression (metabolism) of MYO1B
2) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.14 Pain Relevance 0.03
Real-time RT-PCR analysis revealed that DM administration suppressed the expression of a variety of inflammation-related genes such as macrophage inflammatory protein-2, CXC chemokine, thrombospondin-1, intercellular adhesion molecular-1 and interleukin-6.
Gene_expression (expression) of molecular-1 in macrophage associated with chemokine, inflammation, dextromethorphan and adhesions
3) Confidence 0.06 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15627475 Disease Relevance 1.08 Pain Relevance 0.80

General Comments

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