INT12412

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Context Info
Confidence 0.47
First Reported 1984
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 3.92
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MPG) nucleus (MPG) DNA binding (MPG)
Anatomy Link Frequency
plasma 3
blood 1
brain 1
nucleus 1
MPG (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 28 99.84 Very High Very High Very High
cocaine 14 99.78 Very High Very High Very High
lidocaine 23 99.66 Very High Very High Very High
Abstinence syndrome 1 98.52 Very High Very High Very High
Analgesic 3 96.08 Very High Very High Very High
opiate 1 95.68 Very High Very High Very High
Desipramine 1 95.52 Very High Very High Very High
Nortriptyline 1 94.52 High High
rheumatoid arthritis 2 93.92 High High
Endep 2 93.92 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 4 99.08 Very High Very High Very High
Obesity 30 98.16 Very High Very High Very High
Syndrome 4 98.08 Very High Very High Very High
Stress 5 97.60 Very High Very High Very High
Renal Failure 2 97.28 Very High Very High Very High
Injury 4 97.00 Very High Very High Very High
Rheumatoid Arthritis 2 93.92 High High
Body Weight 2 92.36 High High
Burns 4 91.60 High High
Cirrhosis 2 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tris (2-butoxyethyl) phosphate (TBEP) is a plasticizer used in the rubber stoppers of evacuated blood collection tubes which disrupts the binding of basic drugs to the carrier protein alpha-1-acid glycoprotein (AAG).
AAG Binding (binding) of in blood
1) Confidence 0.47 Published 1984 Journal Clin. Biochem. Section Abstract Doc Link 6518648 Disease Relevance 0 Pain Relevance 0.13
Alpha 1-acid glycoprotein (AAG) and serum protein binding of methadone in heroin addicts with abstinence syndrome.
AAG Binding (binding) of associated with syndrome, methadone and abstinence syndrome
2) Confidence 0.47 Published 2000 Journal Int J Clin Pharmacol Ther Section Title Doc Link 10667835 Disease Relevance 0.10 Pain Relevance 0.24
The effect of in vitro treatment of serum with the alkylating agents carmustine (BCNU) and mechlorethamine on the protein binding of penbutolol, a basic agent mainly bound to alpha 1-acid glycoprotein (AAG), was investigated.
AAG Binding (bound) of
3) Confidence 0.47 Published 1994 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 8174208 Disease Relevance 0 Pain Relevance 0
Plasma binding of imipramine and lidocaine, two drugs that bind predominantly to alpha-1 acid glycoprotein (AAG), and of diazepam and phenytoin, albumin-bound drugs, were studied in fresh human plasma.
AAG Binding (bind) of in plasma associated with lidocaine
4) Confidence 0.47 Published 1985 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 3934087 Disease Relevance 0 Pain Relevance 0.37
In contrast, some studies report that drugs bound to alpha 1-acid glycoprotein (AAG) may have increased binding that is related to increased serum AAG concentration; however, this is not a consistent finding.
AAG Binding (bound) of
5) Confidence 0.47 Published 1986 Journal Clin Pharmacokinet Section Abstract Doc Link 3524955 Disease Relevance 0.78 Pain Relevance 0.21
These results indicate that cocaine is highly bound to serum proteins, primarily albumin and AAG.
AAG Binding (bound) of associated with cocaine
6) Confidence 0.47 Published 1988 Journal Pharm. Res. Section Abstract Doc Link 3247314 Disease Relevance 0 Pain Relevance 0.32
Two classes of binding sites were identified with affinity and capacity constants consistent with binding to alpha-1-acid glycoprotein (AAG) and albumin.
AAG Binding (binding) of
7) Confidence 0.47 Published 1988 Journal Pharm. Res. Section Abstract Doc Link 3247314 Disease Relevance 0 Pain Relevance 0.30
Alpha 1-acid glycoprotein (AAG), a plasma protein that primarily binds basic drugs, has been shown to increase in patients during stress such as trauma or surgery.
AAG Binding (binds) of in plasma associated with stress and injury
8) Confidence 0.47 Published 1989 Journal DICP Section Abstract Doc Link 2763579 Disease Relevance 0.19 Pain Relevance 0.19
Diltiazem is bound as well to alpha 1-acid glycoprotein (AAG) as to albumin.
AAG Binding (bound) of
9) Confidence 0.47 Published 1990 Journal J Clin Pharmacol Section Abstract Doc Link 2341578 Disease Relevance 0.80 Pain Relevance 0.30
The selectivity (binding to S- vs.
AAG Binding (binding) of
10) Confidence 0.36 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3368020 Disease Relevance 0 Pain Relevance 0.34
In contrast, some studies report that drugs bound to alpha 1-acid glycoprotein (AAG) may have increased binding that is related to increased serum AAG concentration; however, this is not a consistent finding.
AAG Binding (binding) of
11) Confidence 0.36 Published 1986 Journal Clin Pharmacokinet Section Abstract Doc Link 3524955 Disease Relevance 0.77 Pain Relevance 0.24
These agents are all bound to serum proteins, mainly to alpha(1)-acid glycoprotein (AAG), but also to human serum albumin.
AAG Binding (bound) of
12) Confidence 0.36 Published 2004 Journal Clin Pharmacokinet Section Abstract Doc Link 14715049 Disease Relevance 0.18 Pain Relevance 0.18
Methadone protein binding was independent of both albumin and AAG concentration.
AAG Binding (independent) of associated with methadone
13) Confidence 0.36 Published 1990 Journal J Clin Pharmacol Section Abstract Doc Link 2303584 Disease Relevance 0.63 Pain Relevance 0.71
OBJECTIVE: Alpha1-acid glycoprotein (AAG) is an acute-phase protein that is responsible for binding basic drugs such as lidocaine (LDC).
AAG Binding (binding) of associated with lidocaine
14) Confidence 0.36 Published 1999 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 10543316 Disease Relevance 0 Pain Relevance 0.62
The objective of this work was to check the effects of alpha-1 acid glycoprotein (AAG) and of its components, A and F1/S genetic variants, on the brain transfer of drugs they bind in plasma.
AAG Binding (bind) of in brain
15) Confidence 0.35 Published 1998 Journal Life Sci. Section Abstract Doc Link 9570346 Disease Relevance 0 Pain Relevance 0.09
The plasma concentrations of alpha 1-acid glycoprotein (AAG), albumin, triglycerides, cholesterol, and total proteins, as well as the plasma binding of racemic, d-methadone, and l-methadone were measured in 45 healthy subjects.
AAG Binding (binding) of in plasma associated with methadone
16) Confidence 0.35 Published 1990 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2311335 Disease Relevance 0 Pain Relevance 0.66
Nuclear protein extracts, western blot and assay for faPy DNA glycosylase activity
faPy DNA glycosylase Binding (activity) of
17) Confidence 0.18 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
Nuclear protein extracts, western blot and assay for faPy DNA glycosylase activity
faPy DNA glycosylase Binding (assay) of
18) Confidence 0.18 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
Similar effects were found with GSH, MPG and NAC but not with enalaprilat.
MPG Binding (found) of
19) Confidence 0.17 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1646324 Disease Relevance 0.14 Pain Relevance 0
Accordingly, it has been shown that hMYH, an adenine-specific glycosylase responsible for removal of the mispaired adenine, localizes to the nucleus and during S-phase associates specifically with the replication foci for immediate post-replicative repair of adenine mispaired with 8-oxoG (64).
glycosylase Binding (associates) of in nucleus
20) Confidence 0.15 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0

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