INT124123

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.00
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
T cells 10
astrocytes 4
macrophages 2
epithelium 2
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 57 99.76 Very High Very High Very High
opiate 14 98.48 Very High Very High Very High
Inflammation 250 97.28 Very High Very High Very High
endometriosis 52 96.96 Very High Very High Very High
dexamethasone 7 92.92 High High
Arthritis 200 89.88 High High
antagonist 17 87.92 High High
opioid receptor 2 87.48 High High
Glutamate 1 86.00 High High
Morphine 8 85.16 High High
Disease Link Frequency Relevance Heat
Adhesions 17 100.00 Very High Very High Very High
Rhinitis 3 99.78 Very High Very High Very High
Viral Meningitis 44 99.60 Very High Very High Very High
Infection 78 99.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 202 99.34 Very High Very High Very High
Endometriosis 90 99.00 Very High Very High Very High
INFLAMMATION 270 97.28 Very High Very High Very High
Heroin Dependence 2 95.36 Very High Very High Very High
Death 19 91.48 High High
Influenza Virus Infection 2 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, PB T cells showed low levels of secreted CCL5 without stimulation, and responded to stimulation by an increased release of CCL5 that was partially inhibited (33% inhibition compared to maximal release) by cyclohexamide (Figure 4).
Positive_regulation (increased) of Localization (release) of CCL5 in T cells
1) Confidence 0.67 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.11 Pain Relevance 0.15
This correlates with reports that the rapid secretion of CCL5 from memory and effector CD8+ T cells is from stored granules, which are thought to be a unique compartment, distinct from lysosomal secretory granules, and that this secretion is resistant to ER and Golgi blockade [36,37,40].
Positive_regulation (resistant) of Localization (secretion) of CCL5 in T cells
2) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.39 Pain Relevance 0.23
This correlates with recent reports that CCL5 secretion from memory and effector CD8+ T cells is from stored granules, thought to be distinct from lysosomal secretory granules, and that this secretion of CCL5 is resistant to ER and Golgi blockade [36,37].
Positive_regulation (resistant) of Localization (secretion) of CCL5 in T cells
3) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.14 Pain Relevance 0.15
This correlates with recent reports that CCL5 secretion from memory and effector CD8+ T cells is from stored granules, thought to be distinct from lysosomal secretory granules, and that this secretion of CCL5 is resistant to ER and Golgi blockade [36,37].
Positive_regulation (resistant) of Localization (secretion) of CCL5 in T cells
4) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.15 Pain Relevance 0.19
Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat.
Positive_regulation (increases) of Localization (release) of RANTES in astrocytes associated with acquired immune deficiency syndrome or hiv infection, opiate and cytokine
5) Confidence 0.23 Published 2005 Journal Glia Section Title Doc Link 15630704 Disease Relevance 0.88 Pain Relevance 0.73
Our findings suggest that opiates may increase the vulnerability of the CNS to viral entry (via recruitment of monocytes/macrophages) and ensuing HIV encephalitis by synergistically increasing MCP-1 and RANTES release by astrocytes.
Positive_regulation (increasing) of Localization (release) of RANTES in astrocytes associated with acquired immune deficiency syndrome or hiv infection, opiate and viral meningitis
6) Confidence 0.23 Published 2005 Journal Glia Section Abstract Doc Link 15630704 Disease Relevance 0.54 Pain Relevance 1.02
The recent evidence suggests that ovarian macrophages migration is a result of RANTES secretion into the environment of endometriomas [28], and their numerous products (IL-1beta, TNF-alfa, Il-6, Il-8, MMP-9, VEGF and others) may be involved in the onset and development of endometriosis [27].
Positive_regulation (result) of Localization (secretion) of RANTES in macrophages associated with endometriosis
7) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.04 Pain Relevance 0.27
Finally, the fourth mechanism is the modulation by statins of surface molecule expression and protein secretion; statins inhibit MHC class-II molecule expression on antigen presenting cells and endothelial cells [13], and CCR5 expression on T lymphocytes [18], while increases the secretion of RANTES and other cytokines [18].
Positive_regulation (increases) of Localization (secretion) of RANTES in T lymphocytes associated with cytokine
8) Confidence 0.16 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.43 Pain Relevance 0.12
The Th2-type cytokine IL-10, however, failed to attenuate RANTES mRNA expression but did inhibit secretion of RANTES induced by a combination of IFN-?
Positive_regulation (induced) of Localization (secretion) of RANTES associated with cytokine
9) Confidence 0.15 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.34 Pain Relevance 0.19
Moreover, some evidence suggests that statins alter the intracellular signals dependent on Rho GTPases [16], the functional activity of LFA-1/ICAM-1 adhesion molecules [17], the expression of the CCR5 coreceptor and the secretion of RANTES [18], and may exert significant modulatory effects on the balance of the cytokine network in human beings [19,20].
Positive_regulation (dependent) of Localization (secretion) of RANTES associated with adhesions and cytokine
10) Confidence 0.12 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.67 Pain Relevance 0.05
Research has shown that JEV infection differentially modulates the induction pattern of reactive oxygen species, IL-6, IL-8, IL-1, MCP-1, RANTES, and MIG secretions in different astrocytic cell lines [45].
Positive_regulation (induction) of Localization (secretions) of RANTES associated with infection
11) Confidence 0.04 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2745699 Disease Relevance 1.17 Pain Relevance 0.22
In vitro, viruses can damage airway epithelium, stimulate muscarinic receptors, and induce eosinophilic influx by stimulating the secretion of RANTES (Johnston et al 1998).
Positive_regulation (stimulating) of Localization (secretion) of RANTES in epithelium associated with rhinitis
12) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2528209 Disease Relevance 1.16 Pain Relevance 0.05

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