INT124136

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.85
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (YWHAZ) mitochondrion (YWHAZ) protein complex (YWHAZ)
cytoplasm (YWHAZ) cytosol (YWHAZ) signal transduction (YWHAZ)
Anatomy Link Frequency
RBL-2H3 4
YWHAZ (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 40 99.82 Very High Very High Very High
Inflammation 83 99.12 Very High Very High Very High
corticosteroid 3 98.52 Very High Very High Very High
antidepressant 15 96.84 Very High Very High Very High
monoamine 5 95.52 Very High Very High Very High
cINOD 28 87.84 High High
sSRI 5 87.64 High High
cOX1 1 78.88 Quite High
COX2 3 78.24 Quite High
cytokine 3 58.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 76 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 3 92.44 High High
Miosis 8 91.12 High High
Ocular Hypertension 8 86.72 High High
Cancer 116 80.16 Quite High
Prostate Cancer 7 73.40 Quite High
Breast Cancer 3 66.48 Quite High
Injury 6 46.28 Quite Low
Autoimmune Disease 1 39.52 Quite Low
Hypersensitivity 2 38.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that fluoxetine induces increases of 14-3-3zeta mRNA, 14-3-3zeta protein and TPH mRNA at 72 h in the RBL-2H3 cells.
Positive_regulation (increases) of 14-3-3zeta in RBL-2H3 associated with fluoxetine
1) Confidence 0.67 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631896 Disease Relevance 0 Pain Relevance 0.85
Fluoxetine-induced up-regulation of 14-3-3zeta and tryptophan hydroxylase levels in RBL-2H3 cells.
Positive_regulation (up-regulation) of 14-3-3zeta in RBL-2H3 associated with fluoxetine
2) Confidence 0.67 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15631896 Disease Relevance 0 Pain Relevance 0.64
We conclude that fluoxetine induces increases of 14-3-3zeta mRNA, 14-3-3zeta protein and TPH mRNA at 72 h in the RBL-2H3 cells.
Positive_regulation (increases) of 14-3-3zeta in RBL-2H3 associated with fluoxetine
3) Confidence 0.49 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631896 Disease Relevance 0 Pain Relevance 0.85
The increase of 14-3-3zeta mRNA was observed at 72 h in the fluoxetine-treated RBL-2H3 cells.
Positive_regulation (increase) of 14-3-3zeta in RBL-2H3 associated with fluoxetine
4) Confidence 0.45 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631896 Disease Relevance 0 Pain Relevance 0.75
The increase of 14-3-3zeta protein was observed at 48 and 72 h.
Positive_regulation (increase) of 14-3-3zeta
5) Confidence 0.45 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631896 Disease Relevance 0 Pain Relevance 0.81
During processes, such as inflammation, arachidonic acid is released from the cell membrane through the activation of phospholipase A2 [1].
Positive_regulation (activation) of phospholipase A2 associated with inflammation
6) Confidence 0.03 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.79 Pain Relevance 0.09
Corticosteroids, the potent anti-inflammatory agents elicit their action by blocking the enzyme phospholipase A2 to inhibit arachidonic acid production, thereby preventing the synthesis of all the PGs, thromboxanes and eicosanoids.
Positive_regulation (enzyme) of phospholipase A2 associated with corticosteroid and inflammation
7) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2751374 Disease Relevance 1.07 Pain Relevance 0.52

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