INT124157

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1, Gnb5) plasma membrane (Oprm1, Gnb5) signal transducer activity (Oprm1, Gnb5)
nucleus (Gnb5)
Anatomy Link Frequency
gray matter 2
Oprm1 (Mus musculus)
Gnb5 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
Central grey 2 99.42 Very High Very High Very High
Intracerebroventricular 4 92.80 High High
Morphine 14 89.84 High High
mu opioid receptor 2 75.00 Quite High
Opioid 4 56.48 Quite High
tolerance 6 54.72 Quite High
MU agonist 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mouse periaqueductal gray matter (PAG) membranes, the mu-opioid receptor (MOR) coprecipitated the alpha-subunits of the Gi/o/z/q/11 proteins, the Gbeta1/2 subunits, and the regulator of G-protein signaling RGS9-2 and its partner protein Gbeta5.
mu-opioid receptor Negative_regulation (coprecipitated) of Gbeta5 in gray matter associated with urological neuroanatomy, opioid receptor and central grey
1) Confidence 0.25 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632124 Disease Relevance 0.20 Pain Relevance 0.60
In mouse periaqueductal gray matter (PAG) membranes, the mu-opioid receptor (MOR) coprecipitated the alpha-subunits of the Gi/o/z/q/11 proteins, the Gbeta1/2 subunits, and the regulator of G-protein signaling RGS9-2 and its partner protein Gbeta5.
MOR Negative_regulation (coprecipitated) of Gbeta5 in gray matter associated with urological neuroanatomy, opioid receptor and central grey
2) Confidence 0.25 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632124 Disease Relevance 0.20 Pain Relevance 0.60

General Comments

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