INT124185

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 57
Total Number 57
Disease Relevance 35.43
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
liver 5
smooth muscle 3
uterus 3
platelet 2
epidermis 2
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 12 100.00 Very High Very High Very High
Kinase C 8 100.00 Very High Very High Very High
addiction 6 99.96 Very High Very High Very High
melanocortin 1 receptor 258 99.62 Very High Very High Very High
Dismenorea 12 94.88 High High
Inflammation 82 94.24 High High
cytokine 73 93.20 High High
Pain 76 90.52 High High
rheumatoid arthritis 66 90.44 High High
Antiemetics 1 90.32 High High
Disease Link Frequency Relevance Heat
Leukemia 97 99.84 Very High Very High Very High
Immunotherapy Of Cancer 21 99.80 Very High Very High Very High
Fibromyalgia 8 99.80 Very High Very High Very High
Gastrointestinal Stromal Tumor 863 99.60 Very High Very High Very High
Cancer 1002 99.36 Very High Very High Very High
Myelodysplastic Syndromes 48 99.20 Very High Very High Very High
Infection 98 98.98 Very High Very High Very High
Targeted Disruption 36 98.88 Very High Very High Very High
Seminoma 17 98.74 Very High Very High Very High
Mastocytosis 137 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of Kit expressing-cells and/or reduced Kit activity during development might have an indirect effect.
Negative_regulation (absence) of Kit
1) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.36 Pain Relevance 0
Imatinib, a c-kit tyrosine kinase inhibitor, has recently been found to be highly effective for patients with advanced GIST.
Negative_regulation (inhibitor) of c-kit associated with gastrointestinal stromal tumor
2) Confidence 0.57 Published 2006 Journal Harefuah Section Abstract Doc Link 16450715 Disease Relevance 0.69 Pain Relevance 0.08
Therapy with this inhibitor of several protein-tyrosine kinases, including ABL, PDGFR, KIT and FMS tyrosine kinase, has been proposed.
Negative_regulation (inhibitor) of KIT associated with fibromyalgia
3) Confidence 0.57 Published 2007 Journal Intern Emerg Med Section Body Doc Link PMC2780604 Disease Relevance 0.86 Pain Relevance 0.04
For this reason, inhibitors of the KIT tyrosine kinase are being developed for the treatment of mastocytosis [1].
Negative_regulation (inhibitors) of KIT associated with mastocytosis
4) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 1.62 Pain Relevance 0
The absence of Kit expressing-cells and/or reduced Kit activity during development might have an indirect effect.
Negative_regulation (reduced) of Kit
5) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.36 Pain Relevance 0
These data open new perspectives for the molecular understanding of juvenile steatosis, the analysis of Kit function during liver development and support the need to follow-up hepatic function in patients during anti-cancer treatment with the inhibitor of KIT activity, STI-571, reported to affect the weight and the viability of rat neonates [61].


Negative_regulation (inhibitor) of KIT in liver associated with immunotherapy of cancer
6) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.10 Pain Relevance 0
Therefore, downregulation of Lpin1 in Kit mutants will lead to a reduced oxidation of lipids and steatosis in a context of increased lipid delivery during suckling.
Negative_regulation (downregulation) of Kit
7) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.29 Pain Relevance 0
Only a controlled inactivation of Kit in blood or liver compartments will help to clearly discriminate the impact of anemia and liver defect in the Kit-dependent impaired post-natal viability.


Negative_regulation (inactivation) of Kit in liver associated with anaemia
8) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.19 Pain Relevance 0
Expression of most of the genes remained unchanged in wild-type and mutant individuals at 10.5 dpp (not shown) except for the very low density lipoprotein receptor (Vldlr), the Lpin1 and the lipoprotein lipase (Lpl) genes that were downregulated in Sco5/Sco5 mutants compared to wild-type littermates (Figure 6).
Negative_regulation (downregulated) of Sco5
9) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.09 Pain Relevance 0.04
Expression of most of the genes remained unchanged in wild-type and mutant individuals at 10.5 dpp (not shown) except for the very low density lipoprotein receptor (Vldlr), the Lpin1 and the lipoprotein lipase (Lpl) genes that were downregulated in Sco5/Sco5 mutants compared to wild-type littermates (Figure 6).
Negative_regulation (downregulated) of Sco5
10) Confidence 0.43 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.09 Pain Relevance 0.04
Therefore, it remains to be determined whether the detected differences in nociceptive responses is due to the absence of mast cells per se or a yet unknown change in the responsiveness of sensory neurons due to a congenital lack of the c-kit receptor.
Negative_regulation (lack) of c-kit in mast cells associated with nociception
11) Confidence 0.42 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 0.75 Pain Relevance 0.46
Moreover, it was their origin that lead to the introduction of a chemotherapeutic regimen, imatinib mesylate, a tyrosine kinase inhibitor for c-kit.
Negative_regulation (inhibitor) of c-kit
12) Confidence 0.42 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 1.43 Pain Relevance 0
While some of the downregulated genes simply reflect the loss of melanocytes (and melanocyte-specific genes), most genes whose expression was altered in KitW-v/KitW-v animals are not melanocyte-specific.
Negative_regulation (altered) of KitW-v in melanocyte
13) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.09 Pain Relevance 0
We identified 430 genes whose expression in the basal epidermis was altered in KitW-v/KitW-v animals: 140 downregulated and 290 upregulated (Figure 4A).
Negative_regulation (altered) of KitW-v in epidermis
14) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.06 Pain Relevance 0
Approximately 10% of the genes downregulated in Mc1re/Mc1re animals were also downregulated in KitW-v/KitW-v animals (Figure 4C), including two genes required for eumelanogenesis, Dopachrome tautomerase and Silver.
Negative_regulation (downregulated) of KitW-v
15) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.07 Pain Relevance 0
While some of the downregulated genes simply reflect the loss of melanocytes (and melanocyte-specific genes), most genes whose expression was altered in KitW-v/KitW-v animals are not melanocyte-specific.
Negative_regulation (altered) of KitW-v in melanocyte
16) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.09 Pain Relevance 0
We identified 430 genes whose expression in the basal epidermis was altered in KitW-v/KitW-v animals: 140 downregulated and 290 upregulated (Figure 4A).
Negative_regulation (altered) of KitW-v in epidermis
17) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.06 Pain Relevance 0
Approximately 10% of the genes downregulated in Mc1re/Mc1re animals were also downregulated in KitW-v/KitW-v animals (Figure 4C), including two genes required for eumelanogenesis, Dopachrome tautomerase and Silver.
Negative_regulation (downregulated) of KitW-v
18) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.07 Pain Relevance 0
The authors postulate that this pattern represents a localized clone of mutant tumor cells developing resistance to c-KIT inhibition.
Negative_regulation (inhibition) of c-KIT associated with cancer
19) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.84 Pain Relevance 0.09
Other new agents are PKC 412 (inhibitor of protein kinase C, KIT, PDGFR, and VEGF), BMS-354825 (tyrosine kinase inhibitor of KIT, PDGFR, abl and src), oblimerson sodium (an antisense oligonucleotide inhibiting BCL-2), and CCI 779 (a rapamycin analogue inhibitor of the protein kinase mammalian target of rapamycin).
Negative_regulation (inhibitor) of KIT associated with kinase c
20) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.49 Pain Relevance 0.05

General Comments

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