INT1242

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Context Info
Confidence 0.42
First Reported 1976
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 4.06
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5)
transmembrane transport (Slc17a5) lysosome (Slc17a5)
Anatomy Link Frequency
body 3
blood 2
plasma 1
white blood cell 1
gum 1
Slc17a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 74 100.00 Very High Very High Very High
Dopamine 5 98.44 Very High Very High Very High
Clonidine 6 97.60 Very High Very High Very High
Ultiva 7 97.52 Very High Very High Very High
Limbic system 1 97.16 Very High Very High Very High
agonist 6 96.56 Very High Very High Very High
noradrenaline 4 95.84 Very High Very High Very High
antagonist 1 83.12 Quite High
Analgesic 3 81.72 Quite High
Calcium channel 1 78.40 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 14 99.66 Very High Very High Very High
Body Weight 19 98.72 Very High Very High Very High
Urological Neuroanatomy 15 97.48 Very High Very High Very High
Cancer 3 97.32 Very High Very High Very High
Necrosis 5 97.08 Very High Very High Very High
Multiple Organ Failure 36 96.24 Very High Very High Very High
Overdose 5 94.64 High High
Injury 45 88.36 High High
Death 9 86.32 High High
Apoptosis 18 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The accumulation of Dopa, as induced by the inhibitor of aromatic amino acid decarboxylase, NSD 1015, was measured in parallel in two dopamine-rich regions, i.e. the limbic system and the corpus striatum, and in two noradrenaline-rich regions, i.e. the neocortex and the lower brain stem.
Negative_regulation (inhibitor) of NSD in brain stem associated with dopamine, noradrenaline and limbic system
1) Confidence 0.42 Published 1976 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 181681 Disease Relevance 0.06 Pain Relevance 0.62
However, no additional reduction in plasma levels of AST and ALT was observed when sodium sulphate was co-administered with NAC.
Neg (no) Negative_regulation (reduction) of AST in plasma
2) Confidence 0.37 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.15 Pain Relevance 0.72
Arabic gum administration dramatically reduced acetaminophen-induced hepatotoxicity as evidenced by reduced serum alanine (ALT) and aspartate aminotransferase (AST) activities.
Negative_regulation (reduced) of AST in gum associated with paracetamol and hepatotoxicity
3) Confidence 0.36 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 14527829 Disease Relevance 0.43 Pain Relevance 0.90
RESULTS: The activities of serum ALT and AST were significantly decreased and both necrosis and inflammatory infiltration were improved in the mice treated with sHSS 3.0 and 1.5 mg.kg-1. sHSS (3.0 mg.kg-1) prevented the ultrastructural changes of hepatocytes caused by AAP, decreased the percentage of apoptotic cells, and downregulated the expression level of Fas mRNA.
Negative_regulation (decreased) of AST in apoptotic cells
4) Confidence 0.34 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.08 Pain Relevance 0
BUN and serum creatinine, ALT and AST levels which were increased significantly following AA treatment decreased significantly after pretreatment with either vitamin E, melatonin or NAC; however, they were not reduced to control levels.
Negative_regulation (decreased) of AST associated with paracetamol
5) Confidence 0.33 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12823615 Disease Relevance 0.51 Pain Relevance 0.68
The mouse model of CLP was used to observe ALT and AST activity, white blood cell count in BALF and myeloperoxidase (MPO).
Negative_regulation (observe) of AST in white blood cell associated with urological neuroanatomy
6) Confidence 0.24 Published 2010 Journal Mol. Biol. Rep. Section Abstract Doc Link 19757155 Disease Relevance 0.25 Pain Relevance 0.35
The ALT and AST levels were also increased significantly (P < 0.001) after acetaminophen treatment but were not reduced with MESNA.
Neg (not) Negative_regulation (reduced) of AST associated with paracetamol
7) Confidence 0.23 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.24 Pain Relevance 0.78
Prior to AAP treatment, the mice pretreated with FSSC showed significantly reduced levels of alanine aminotransferase (ALT) and aspirate aminotransferase (AST) activity.
Negative_regulation (reduced) of AST associated with paracetamol
8) Confidence 0.22 Published 2008 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 18838823 Disease Relevance 0.31 Pain Relevance 0.64
Administration of aqueous stem extract (400 mg/kg body weight, orally) and aqueous leaves extract (400 mg/kg body weight, orally) along with the lead nitrate (5 mg/kg body weight, i.p. for 30 days) increased the activities of SOD and CAT and decreased the levels of AST, ALT, ALP, and ACP enzymes in mice.
Negative_regulation (decreased) of AST in body associated with body weight
9) Confidence 0.20 Published 2010 Journal Toxicology International Section Abstract Doc Link PMC2964743 Disease Relevance 0.52 Pain Relevance 0
Four hours after the acetaminophen injection, mice were decapitated and their blood was taken to determine serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and tumor necrosis factor-alpha (TNF-alpha) levels.
Spec (determine) Negative_regulation (determine) of AST in blood associated with necrosis, paracetamol and cancer
10) Confidence 0.19 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16822497 Disease Relevance 0.45 Pain Relevance 0.41
The hepatotoxic dose of CCl(4) (1.5 ml/kg; orally) also raised the serum AST and ALT levels.
Negative_regulation (raised) of serum AST
11) Confidence 0.17 Published 2002 Journal Fitoterapia Section Abstract Doc Link 12490212 Disease Relevance 0.25 Pain Relevance 0.42
To further confirm these data, we found that GW0742 treatment not only prevents lung dysfunction, and reduces zymosan-induced loss of blood PaO2, PCO2, HCO3- and pH levels, but also diminishes other blood parameters, such as the levels of AST, ALT, bilirubin and alkaline phosphatase that are altered after the onset of zymosan-induced MOF.
Negative_regulation (diminishes) of AST in blood associated with multiple organ failure
12) Confidence 0.12 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.69 Pain Relevance 0
After administration of rAPSL at concentrations of 3.0 mg/kg body wt and 1.0 mg/kg body wt, the serum AST levels were decreased by 40.4% and 18.1%, respectively; while the ALT levels of serum were decreased by 44.2% and 33.6%, respectively, compared with the respective serum AST and ALT levels in the model group.
Negative_regulation (decreased) of serum AST in body
13) Confidence 0.10 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707046 Disease Relevance 0.07 Pain Relevance 0.04
After administration of rAPSL at concentrations of 3.0 mg/kg body wt and 1.0 mg/kg body wt, the serum AST levels were decreased by 40.4% and 18.1%, respectively; while the ALT levels of serum were decreased by 44.2% and 33.6%, respectively, compared with the respective serum AST and ALT levels in the model group.
Negative_regulation (decreased) of serum AST in body
14) Confidence 0.10 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707046 Disease Relevance 0.05 Pain Relevance 0.04
Pretreatment of rats with CSE (500 mg/kg orally for 2 days at 12 h intervals) prevented paracetamol (640 mg/kg) and CCl4 (150 ml/kg)-induced rise in serum alkaline phosphatase (ALP) and aminotransferases (AST and ALT).
Negative_regulation (prevented) of AST associated with paracetamol
15) Confidence 0.04 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15763373 Disease Relevance 0 Pain Relevance 0.18

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