INT124210

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.39
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
coronary artery 1
neuronal 1
cartilage 1
brain 1
CGp 1
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 8 90.48 High High
Pain 6 87.80 High High
Inflammatory marker 3 86.40 High High
Inflammation 19 75.12 Quite High
Anterior cingulate cortex 30 74.80 Quite High
Hippocampus 5 67.60 Quite High
rheumatoid arthritis 1 60.72 Quite High
Transcranial magnetic stimulation 5 37.04 Quite Low
imagery 6 11.20 Low Low
Analgesic 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 76 99.58 Very High Very High Very High
Cognitive Disorder 120 99.48 Very High Very High Very High
Osteoarthritis 8 90.48 High High
Pain 3 87.80 High High
INFLAMMATION 21 86.08 High High
Diabetes Mellitus 71 81.68 Quite High
Calcification 93 76.64 Quite High
Atherosclerosis 19 66.28 Quite High
Disorder Of Lipid Metabolism 9 60.80 Quite High
Rheumatoid Arthritis 1 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical markers of cartilage metabolism further support the efficacy of SP in men as indicated by a significant increase in serum level of IGF-I and a significant decrease in serum level of YKL-40 compared to MP.
Negative_regulation (decrease) of YKL-40 in cartilage
1) Confidence 0.12 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15636169 Disease Relevance 0.75 Pain Relevance 0.52
Within this context, deeper firing rate suppression in CGp facilitates task switching.
Negative_regulation (suppression) of CGp
2) Confidence 0.12 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3001991 Disease Relevance 0.37 Pain Relevance 0
Collectively, therefore, these results endorse an emerging idea that reductions in neuronal activity in CGp specifically, and the default network more generally, are necessary for cognitive control (Gusnard and Raichle, 2001; Raichle et al., 2001; Raichle and Mintun, 2006; Mason et al., 2007; Buckner et al., 2008; Hayden et al., 2009).
Negative_regulation (reductions) of CGp in neuronal associated with cognitive disorder
3) Confidence 0.12 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3001991 Disease Relevance 0.32 Pain Relevance 0.14
These findings indicate that suppression of neuronal activity in CGp contributes to cognitive control, and suggest that activity in the default network reflects processes that directly compete with control processes elsewhere in the brain.


Negative_regulation (suppression) of CGp in brain associated with cognitive disorder
4) Confidence 0.12 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3001991 Disease Relevance 0.24 Pain Relevance 0
Together, these results suggest that reduced CGp activity indexes control processes that dictate switching efficiency, and that such processes are most engaged on efficient (i.e., rapid) switch trials, less engaged on inefficient (i.e., slow) switch trials, and least engaged on non-switch trials.
Negative_regulation (reduced) of CGp
5) Confidence 0.10 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3001991 Disease Relevance 0 Pain Relevance 0
These findings indicate that suppression of neuronal activity in CGp facilitates cognitive control, and suggest that activity in the default network reflects processes that directly compete with control processes elsewhere in the brain.



Negative_regulation (suppression) of CGp in CGp associated with cognitive disorder
6) Confidence 0.09 Published 2010 Journal Frontiers in Human Neuroscience Section Abstract Doc Link PMC3001991 Disease Relevance 0.37 Pain Relevance 0
In a recent study of patients with stable coronary artery disease (CAD), it was shown that YKL-40 levels were significantly reduced in statin treated patients compared to non-treated patients [37].
Negative_regulation (reduced) of YKL-40 in coronary artery associated with coronary artery disease
7) Confidence 0.07 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.33 Pain Relevance 0.19

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