INT124211

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Context Info
Confidence 1.00
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.29
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
cartilage 1
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 92.44 High High
Osteoarthritis 8 89.44 High High
rheumatoid arthritis 1 83.76 Quite High
Inflammation 2 56.64 Quite High
Somatostatin 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 3 92.44 High High
Osteoarthritis 8 89.44 High High
Growth Problems 3 85.64 High High
Rheumatoid Arthritis 1 83.76 Quite High
Disease 1 83.28 Quite High
Injury 1 82.80 Quite High
Arthralgia 1 81.80 Quite High
INFLAMMATION 2 56.64 Quite High
Thyroid Disease 2 53.92 Quite High
Nutritional Deficiencies 5 53.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand the variability between laboratories in analyzing IGF-1 levels and the high level of post-sampling proteolysis of IGF-1 make the diagnosis of severe IGFD more difficult.25,26
Protein_catabolism (proteolysis) of IGF-1
1) Confidence 1.00 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.33 Pain Relevance 0.03
Serum levels of glycoprotein 39 (YKL-40), a marker of cartilage degradation, and insulin-like growth factor-I (IGF-I), a growth factor associated with cartilage synthesis, were assessed at baseline and at the end of the study.
Protein_catabolism (degradation) of IGF-I in cartilage
2) Confidence 0.11 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15636169 Disease Relevance 0.96 Pain Relevance 0.60

General Comments

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