INT124218

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 23
Disease Relevance 19.55
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1) lipid metabolic process (Pon1)
Anatomy Link Frequency
liver 9
blood 2
molar 1
Pon1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 229 96.84 Very High Very High Very High
fibrosis 30 91.60 High High
alcohol 15 67.04 Quite High
anesthesia 31 63.36 Quite High
chemokine 15 53.84 Quite High
Inflammatory response 15 39.68 Quite Low
cytokine 15 32.60 Quite Low
imagery 15 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 214 99.68 Very High Very High Very High
Disorder Of Lipid Metabolism 1128 99.60 Very High Very High Very High
Nicotine Addiction 3 99.24 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 15 98.80 Very High Very High Very High
Stress 243 98.76 Very High Very High Very High
Disease 89 98.68 Very High Very High Very High
Hepatotoxicity 30 98.36 Very High Very High Very High
Cirrhosis 255 98.08 Very High Very High Very High
INFLAMMATION 244 96.84 Very High Very High Very High
Diabetes Mellitus 92 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Not much is known about the biochemical mechanisms underlying these alterations in PON1 synthesis and secretion in liver diseases.
Gene_expression (synthesis) of PON1 in liver associated with liver disease
1) Confidence 0.75 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.17 Pain Relevance 0.10
In previous studies, we reported that serum PON1 activity is decreased in patients with chronic liver impairment, while serum PON1 concentration and hepatic PON1 protein expression are increased [21-23].
Gene_expression (expression) of PON1 protein in liver
2) Confidence 0.75 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.16 Pain Relevance 0.12
Interestingly, Liu et al. [54] observed that when they produced recombinant human PON1 in a baculovirus system in Hi5 insect cells, a significant proportion of PON1 was synthesized as a protein of approximately 54,000 Da, and which they identified as a PON1 multimer.
Gene_expression (produced) of PON1
3) Confidence 0.75 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.80 Pain Relevance 0
Taking these data together, we can hypothesize that abnormal PON1 molecules are synthesized under diverse altered conditions such as liver disease, or when human PON1 is synthesized by phylogenetically-distant cells.
Gene_expression (synthesized) of PON1 in liver associated with liver disease
4) Confidence 0.75 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.78 Pain Relevance 0
To investigate the differential expression of PON1 protein in normal and diseased livers, we employed the model of CCl4-induced hepatic damage in rats [26].
Spec (investigate) Gene_expression (expression) of PON1 protein in livers
5) Confidence 0.75 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.08 Pain Relevance 0.15
The liver plays a key role in the synthesis of PON1 [18], and chronic liver diseases are associated with increased oxidative stress, MCP-1 synthesis, and inflammation [19,20].
Gene_expression (synthesis) of PON1 in liver associated with stress, liver disease and inflammation
6) Confidence 0.66 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.20 Pain Relevance 0.19
Taking these data together, we can hypothesize that abnormal PON1 molecules are synthesized under diverse altered conditions such as liver disease, or when human PON1 is synthesized by phylogenetically-distant cells.
Gene_expression (synthesized) of PON1 in liver associated with liver disease
7) Confidence 0.66 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.83 Pain Relevance 0
In addition, results from the present study suggest that these small particles do not carry PON1 and, as such, would contribute to the decrease in serum PON1 activity observed.
Neg (not) Gene_expression (carry) of PON1
8) Confidence 0.65 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.00 Pain Relevance 0.05
Abnormal immunoreactive protein reaction against anti-PON1 antibodies
Gene_expression (antibodies) of PON1
9) Confidence 0.65 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.41 Pain Relevance 0
Conversely, there is strong evidence showing that “high-expressor” PON1 alleles influence macrovascular disease.
Gene_expression (expressor) of PON1 associated with disease
10) Confidence 0.64 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 1.08 Pain Relevance 0
Divergent results may be explained by differences in ethnicity, age, sample size, smoking, diet, concomitant medications (16), PON1 assays, and differing relationships between PON activity or genotype for initiation and progression of complications.
Gene_expression (assays) of PON1 associated with nicotine addiction
11) Confidence 0.64 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 1.23 Pain Relevance 0
The presence of the LL genotype and two other PON1 polymorphisms was found to influence urinary albumin excretion in 156 Caucasian type 1 diabetic adolescents (9).
Gene_expression (presence) of PON1 associated with diabetes mellitus
12) Confidence 0.64 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 1.16 Pain Relevance 0
Interestingly, Liu et al. [54] observed that when they produced recombinant human PON1 in a baculovirus system in Hi5 insect cells, a significant proportion of PON1 was synthesized as a protein of approximately 54,000 Da, and which they identified as a PON1 multimer.
Gene_expression (synthesized) of PON1
13) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.78 Pain Relevance 0
Paraoxonase-1 (PON1), a lactonase synthesized by the liver, circulates in blood bound to high-density lipoproteins (HDL).
Gene_expression (synthesized) of PON1 in blood associated with disorder of lipid metabolism
14) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2877049 Disease Relevance 0.39 Pain Relevance 0.04
More recent evidence indicates that PON1 over-expression provides strong protection against the development of experimental liver disease [24].
Gene_expression (-) of PON1 in liver associated with liver disease
15) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.15 Pain Relevance 0.12
More recent evidence indicates that PON1 over-expression provides strong protection against the development of experimental liver disease [24].
Gene_expression (over) of PON1 in liver associated with liver disease
16) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.15 Pain Relevance 0.12
More recent evidence indicates that PON1 over-expression provides strong protection against the development of experimental liver disease [24].
Gene_expression (expression) of PON1 in liver associated with liver disease
17) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.15 Pain Relevance 0.12
Of note, PON1 levels were significantly lower on postoperative day 1 than during the preoperative period in the LC group.
Gene_expression (levels) of PON1
18) Confidence 0.55 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 0.49 Pain Relevance 0
Patients had significantly increased serum MDA concentrations (p < 0.001) and there were strong negative correlations (p < 0.001) between serum PON1 and MDA levels in the acute myocardial infarction group (r = -0.673), in the unstable angina pectoris group (r = -0.868) and in healthy controls (r = -0.778).
Gene_expression (levels) of PON1
19) Confidence 0.55 Published 2004 Journal Acta Cardiol Section Body Doc Link 15636443 Disease Relevance 0.23 Pain Relevance 0
Paraoxonase-1 (PON1), a lactonase synthesized by the liver, circulates in blood bound to high-density lipoproteins (HDL).
Gene_expression (synthesized) of Paraoxonase-1 in blood associated with disorder of lipid metabolism
20) Confidence 0.51 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2877049 Disease Relevance 0.39 Pain Relevance 0.04

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