INT124220

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 7.84
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1) lipid metabolic process (Pon1)
Anatomy Link Frequency
liver 2
fascia 1
Pon1 (Rattus norvegicus)
Pon1 - Q192R (1) Pon1 - A632G (1)
Pain Link Frequency Relevance Heat
Inflammation 54 99.60 Very High Very High Very High
Inflammatory response 14 93.64 High High
cytokine 6 91.60 High High
ischemia 60 89.16 High High
Angina 3 50.00 Quite Low
chemokine 2 49.20 Quite Low
cINOD 6 48.88 Quite Low
Pain 4 44.88 Quite Low
ketamine 8 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 166 99.92 Very High Very High Very High
INFLAMMATION 69 99.60 Very High Very High Very High
Stress 56 99.40 Very High Very High Very High
Breast Cancer 5 98.88 Very High Very High Very High
Disease 20 97.36 Very High Very High Very High
Injury 92 96.40 Very High Very High Very High
Cancer 5 94.92 High High
Diabetes Mellitus 112 92.68 High High
Adhesions 6 91.48 High High
Cv Unclassified Under Development 60 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is also possible that changes in HDL size are associated with firmer binding of PON1 but not with changes in activity.
PON1 Binding (binding) of associated with disorder of lipid metabolism
1) Confidence 0.47 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.96 Pain Relevance 0.04
In this study, we investigated the association of two common, nonsynonymous polymorphisms in the PON1 gene (Q192R and L55M) with breast cancer risk in postmenopausal women through a nested case-control study within the American Cancer Society Cancer Prevention Study II Nutrition Cohort.
PON1 (Q192R) Binding (association) of associated with cancer and breast cancer
2) Confidence 0.43 Published 2006 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 16775186 Disease Relevance 0.56 Pain Relevance 0
Experimental data show a clear link between PON1, HDL and inflammation.
PON1 Spec (clear) Binding (link) of associated with inflammation and disorder of lipid metabolism
3) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.45 Pain Relevance 0.25
These results support the association between PON1 gene polymorphisms and plantar fascia changes.
PON1 gene Binding (association) of in fascia
4) Confidence 0.35 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 0.18 Pain Relevance 0
The low-activity allele at the PON1 gene has also been associated with a less harmful lipoprotein profile (23).
PON1 gene Binding (associated) of
5) Confidence 0.35 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 0.46 Pain Relevance 0
PON1 activity
PON1 Binding (activity) of
6) Confidence 0.35 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 0 Pain Relevance 0
PON1 genotyping
PON1 Binding (genotyping) of
7) Confidence 0.35 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 0.11 Pain Relevance 0
CONCLUSIONS: Results of this study indicate that lower serum PON1 activity is associated with oxidative stress and the activity of PON1 is not related to HDL-cholesterol.


PON1 Binding (associated) of
8) Confidence 0.25 Published 2004 Journal Acta Cardiol Section Body Doc Link 15636443 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese.


PON1 (A632G) Binding (association) of
9) Confidence 0.24 Published 2005 Journal Circ. J. Section Body Doc Link 16308493 Disease Relevance 0.06 Pain Relevance 0
Paraoxonase and arylesterase are similar gene?
arylesterase Binding (gene) of
10) Confidence 0.15 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 0.90 Pain Relevance 0.15
Paraoxonase and arylesterase are similar gene?
Paraoxonase Binding (gene) of
11) Confidence 0.15 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 0.90 Pain Relevance 0.15
The antioxidant system has an important role in protection from the damage of oxidative stress.16,21,23,26 In our study, by measuring the liver tissue catalase, paraoxonase, arylesterase, ceruloplasmin, and lipid hydroperoxide levels, we obtained information about hepatic IR injury.
paraoxonase Binding (measuring) of in liver associated with stress and injury
12) Confidence 0.15 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 1.13 Pain Relevance 0.20
The antioxidant system has an important role in protection from the damage of oxidative stress.16,21,23,26 In our study, by measuring the liver tissue catalase, paraoxonase, arylesterase, ceruloplasmin, and lipid hydroperoxide levels, we obtained information about hepatic IR injury.
arylesterase Binding (measuring) of in liver associated with stress and injury
13) Confidence 0.13 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 1.13 Pain Relevance 0.20

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